Human FABP2 Recombinant Protein (RPPB3494)
- SKU:
- RPPB3494
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P12104
Description
| Product Name: | Human FABP2 Recombinant Protein |
| Product Code: | RPPB3494 |
| Size: | 25µg |
| Species: | Human |
| Target: | FABP2 |
| Synonyms: | Fatty acid-binding protein 2, IFABP, I-FABP, FABPI, FABP-2, Fatty acid-binding protein intestinal, FABP2, MGC133132. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless liquid formulation. |
| Formulation: | FABP2 His-Tag is supplied in 20mM Tris-HCl pH 8 and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.Please avoid freeze thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH�MAFDSTWKVD RSENYDKFME KMGVNIVKRK LAAHDNLKLT ITQEGNKFTV KESSAFRNIE VVFELGVTFN YNLADGTELR GTWSLEGNKL IGKFKRTDNG NELNTVREII GDELVQTYVY EGVEAKRIFK KD |
FABP multigene family has almost 20 known members. FABPs are divided into 3 different types: hepatic, intestinal and cardiac which form 14-15 kDa proteins that take part in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. FABPs are involved in the modulation of cell growth and proliferation. Intestinal FABP (FABP2) gene has a polymorphism at codon 54 that identified an alanine-encoding allele and a threonine-encoding allele. Thr-54 protein is associated with increased fat oxidation and insulin resistance. High serum levels of FABP2 is ulcerative colitis indicates ileitis. FABP2 is has part in triglyceride-rich lipoprotein synthesis. FABP2 binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long- chain fatty acids. FABP2 helps maintain energy homeostasis by functioning as a lipid sensor.
FABP2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 132 amino acids and having a molecular mass of 17.3kDa. FABP2 is fused to a 20 aa His tag at N-terminus and purified by standard chromatography techniques.
| UniProt Protein Function: | FABP2: FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long- chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 4q28-q31 Cellular Component: cytoplasm Molecular Function:transporter activity; fatty acid binding Biological Process: transport; digestion |
| NCBI Summary: | The intracellular fatty acid-binding proteins (FABPs) belong to a multigene family with nearly twenty identified members. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Intestinal fatty acid-binding protein 2 gene contains four exons and is an abundant cytosolic protein in small intestine epithelial cells. This gene has a polymorphism at codon 54 that identified an alanine-encoding allele and a threonine-encoding allele. Thr-54 protein is associated with increased fat oxidation and insulin resistance. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P12104 |
| NCBI GenInfo Identifier: | 119805 |
| NCBI Gene ID: | 2169 |
| NCBI Accession: | P12104.2 |
| UniProt Secondary Accession: | P12104,Q2NKJ1, |
| UniProt Related Accession: | P12104 |
| Molecular Weight: | 132 |
| NCBI Full Name: | Fatty acid-binding protein, intestinal |
| NCBI Synonym Full Names: | fatty acid binding protein 2, intestinal |
| NCBI Official Symbol: | FABP2�� |
| NCBI Official Synonym Symbols: | FABPI; I-FABP�� |
| NCBI Protein Information: | fatty acid-binding protein, intestinal; fatty acid-binding protein 2; intestinal-type fatty acid-binding protein |
| UniProt Protein Name: | Fatty acid-binding protein, intestinal |
| UniProt Synonym Protein Names: | Fatty acid-binding protein 2; Intestinal-type fatty acid-binding protein; I-FABP |
| Protein Family: | Fatty acid-binding protein |
| UniProt Gene Name: | FABP2�� |
| UniProt Entry Name: | FABPI_HUMAN |
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