Chemokines Recombinant Proteins

Human Exodus 2 Recombinant Protein (RPPB1131)

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SKU:
RPPB1131
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O00585
Research Area:
Chemokines

Description

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Product Name:Human Exodus 2 Recombinant Protein
Product Code:RPPB1131
Size:20µg
Species:Human
Target:Exodus 2
Synonyms:Small inducible cytokine A21, CCL21, Beta chemokine exodus-2, 6Ckine, Secondary lymphoid-tissue chemokine, SLC, chemokine (C-C motif) ligand 21, ECL, CKb9, TCA4, SCYA21, MGC34555.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:Lyophilized from a 0.2�m filtered concentrated solution in 20mM Phosphate Buffer, pH 7.4 and 150mM NaCl.
Solubility:It is recommended to reconstitute the lyophilized Exodus2 in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized Exodus-2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL21 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Purity:Greater than 97.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Amino Acid Sequence:SDGGAQDCCL KYSQRKIPAK VVRSYRKQEP SLGCSIPAIL FLPRKRSQAE LCADPKELWV QQLMQHLDKT PSPQKPAQGC RKDRGASKTG KKGKGSKGCR KTERSQTPKG P
Biological Activity:Determined by its ability to chemoattract human total lymphocyte population using a concentration range of 10-100ng/ml.

Chemokine (C-C motif) ligand 21 (CCL21) is a small cytokine belonging to the CC chemokine family. This chemokine is also known as 6Ckine (because it has six conserved cysteine residues instead of the four cysteines typical to chemokines), exodus-2, and secondary lymphoid-tissue chemokine (SLC). CCL21 is expressed predominantly in the lymph nodes and, in contrast to other CC chemokines, is chemotactic for lymphocytes. The gene for CCL21 is located on human chromosome 9. CCL21 elicits its effects by binding to a cell surface chemokine receptor known as CCR7.

Exodus-2 Human Recombinant produced in E.Coli as a single, non-glycosylated, polypeptide chain containing 111 amino acids and having a molecular mass of 12219 Dalton. The CCL21 is purified by proprietary chromatographic techniques.

NCBI Summary:This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19). [provided by RefSeq, Sep 2014]
UniProt Code:O00585
NCBI GenInfo Identifier:6094386
NCBI Gene ID:6366
NCBI Accession:O00585.1
UniProt Related Accession:O00585
Molecular Weight:
NCBI Full Name:C-C motif chemokine 21
NCBI Synonym Full Names:C-C motif chemokine ligand 21
NCBI Official Symbol:CCL21��
NCBI Official Synonym Symbols:ECL; SLC; CKb9; TCA4; 6Ckine; SCYA21��
NCBI Protein Information:C-C motif chemokine 21
UniProt Protein Name:C-C motif chemokine 21
UniProt Synonym Protein Names:6Ckine; Beta-chemokine exodus-2; Secondary lymphoid-tissue chemokine; SLC; Small-inducible cytokine A21
Protein Family:C-C motif chemokine
UniProt Gene Name:CCL21��
UniProt Entry Name:CCL21_HUMAN
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