Human EPO Receptor/EPOR Recombinant Protein (RPES1201)
- SKU:
- RPES1201
Description
Human EPO Receptor/EPOR Recombinant Protein
Erythropoietin (EPO) is the major glycoprotein hormone regulator of mammalian erythropoiesis, and is produced by kidney and liver in an oxygen-dependent manner. The biological effects of EPO are mediated by the specific erythropoietin receptor (EPOR/EPO Receptor) on bone marrow erythroblasts, which transmits signals important for both proliferation and differentiation along the erythroid lineage. EPOR protein is a type â… single-transmembrane cytokine receptor, and belongs to the homodimerizing subclass which functions as ligand-induced or ligand-stabilized homodimers. EPOR signaling prevents neuronal death and ischemic injury. Recent studies have shown that EPO and EPOR protein may be involved in carcinogenesis, angiogenesis, and invasion.
| Product Name: | Human EPO Receptor/EPOR Recombinant Protein (RPES1201) |
| Product Code: | RPES1201 |
| Size: | 50µg |
| Species: | Human |
| Expressed Host: | HEK293 Cells |
| Synonyms: | EPO-R |
| Accession: | NP_000112.1 |
| Sequence: | Met 1-Pro 250 |
| Fusion tag: | C-His |
| Activity: | Measured by its ability to inhibit EPO-dependent proliferation of TF-1 human erythroleukemic cells.The ED50 for this effect is typically 15-60 ng/mL in the presence of 0.1 U/mL Recombinant Human EPO. |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the extracellular domain (Met 1-Pro 250) of human erythropoietin receptor (NP_000112.1) precursor was fused with a polyhistidine tag at the C-terminus. |
| Purity: | > 98 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 26.3 kDa |
| AP Mol Mass: | 34 kDa |
| Formulation: | Lyophilized from sterile PBS, pH 7.4 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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