Human EphB4/HTK Recombinant Protein (RPES5137)
- SKU:
- RPES5137
- Product Type:
- Recombinant Protein
- Species:
- Human
Description
Human EphB4/HTK Recombinant Protein
Ephrin type-B receptor 4 is a protein that in humans is encoded by the EPHB4 gene. It is a single-pass type I membrane protein belonging to the ephrin receptor subfamily of protein kinase superfamily. Members of the ephrin and Eph family are local mediators of cell function through largely contact-dependent processes in development and in maturity. Furthermore; EphB4 protein and the corresponding ligand Ephrin-B2 contribute to tumor growth in various human tumors. EphB4 protein has tumor suppressor activities and that regulation of cell proliferation; extracellular matrix remodeling; and invasive potential are important mechanisms of tumor suppression. Therefore; Ephrin-B2/EphB4 may be recognized as a novel prognostic indicator for cancers.
| Product Name: | Human EphB4/HTK Recombinant Protein (RPES5137) |
| Product Code: | RPES5137 |
| Size: | 100µg |
| Species: | Human |
| Expressed Host: | HEK293 Cells |
| Synonyms: | HTK,MYK1,TYRO11 |
| Accession: | NP_004435.3 |
| Sequence: | Met 1-Ala 539 |
| Fusion tag: | C-Fc |
| Activity: | Measured by its binding ability in a functional ELISA. Immobilized human EFNB2 at 2 µg/ml (100 ?l/well) can bind human EphB4-Fc with a linear ranger of 1.56-12.5 ng/ml. |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the extracellular domain (Met 1-Ala 539) of human EphB4 (NP_004435.3) precursor was expressed with the fused Fc region of human IgG1 at the C-terminus. |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 83.8 kDa |
| AP Mol Mass: | 105-115 kDa |
| Formulation: | Lyophilized from sterile PBS; pH 7.4 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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