Growth Factors & Cytokines Recombinant Proteins

Human EPGN Recombinant Protein (RPPB0184)

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RPPB0184

Description

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Product Name:Human EPGN Recombinant Protein
Product Code:RPPB0184
Size:10µg
Species:Human
Target:EPGN
Synonyms:Epithelial mitogen,� EPG, Epithelial Mitogen Homolog (Mouse), Epithelial Mitogen Homolog, ALGV3072, PRO9904, Epigen, EPGN.
Source:Sf9 Insect cells
Physical Appearance:Sterile filtered colorless solution.
Formulation:EPGN protein solution (0.5mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:ADPAAVTVTP PITAQQGNWT VNKTEADNIE GPIALKFSHL CLEDHNSYCI NGACAFHHEL EKAICRCFTG YTGERCEHLT LTSYAVDSYE KHHHHHH

EPGN is an EGF-related polypeptide growth factor that signals through the ErbB receptor-1. EPGN is produced in numerous tissues, including the testis, liver, heart and in certain tumor cells. EPGN is mitogenic for fibroblasts and epithelial cells. Human EPGN is originally synthesized as a glycosylated 14.7 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce a mature soluble sequence.

EPGN produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 97 amino acids (23-110a.a.) and having a molecular mass of 10.8kDa (Molecular size on SDS-PAGE will appear at approximately 13.5-18kDa).EPGN is expressed with an 9 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:Epigen: Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases. 7 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Ligand, receptor tyrosine kinaseChromosomal Location of Human Ortholog: 4q13.3Cellular Component: extracellular space; integral to plasma membrane; intracellularMolecular Function: epidermal growth factor receptor binding; growth factor activityBiological Process: activation of MAPK activity; angiogenesis; epidermal growth factor receptor signaling pathway; MAPKKK cascade; positive regulation of cell proliferation; positive regulation of epidermal growth factor receptor activity; positive regulation of epithelial cell proliferation; positive regulation of MAP kinase activity; positive regulation of mitosis
UniProt Protein Details:
NCBI Summary:The protein encoded by this gene is a member of the epidermal growth factor family. Members of this family are ligands for the epidermal growth factor receptor and play a role in cell survival, proliferation and migration. This protein has been reported to have high mitogenic activity but low affinity for its receptor. Expression of this transcript and protein have been reported in cancer specimens of the breast, bladder, and prostate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
UniProt Code:Q6UW88
NCBI GenInfo Identifier:229464464
NCBI Gene ID:255324
NCBI Accession:Q6UW88.2
UniProt Secondary Accession:Q6UW88,A1BMM3, A1BMM4, A1BMM5, A1BMM6, A1BMM7, A1BMM8 A8K090
UniProt Related Accession:Q6UW88
Molecular Weight:
NCBI Full Name:Epigen
NCBI Synonym Full Names:epithelial mitogen
NCBI Official Symbol:EPGN��
NCBI Official Synonym Symbols:EPG; PRO9904; ALGV3072��
NCBI Protein Information:epigen
UniProt Protein Name:Epigen
UniProt Synonym Protein Names:Epithelial mitogen; EPG
Protein Family:Epigen
UniProt Gene Name:EPGN��
UniProt Entry Name:EPGN_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q6UW88
Research Area:
Growth Factors & Cytokines
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