Chemokines Recombinant Proteins

Human Eotaxin Recombinant Protein (RPPB1123)

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RPPB1123

Description

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Product Name:Human Eotaxin Recombinant Protein
Product Code:RPPB1123
Size:20µg
Species:Human
Target:Eotaxin
Synonyms:Small inducible cytokine A11, CCL11, Eosinophil chemotactic protein, chemokine (C-C motif) ligand 11, SCYA11, MGC22554.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:Eotaxin-His is supplied liquid In Phosphate Buffered Saline pH7.4 containing 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGPASVPTTC CFNLANRKIP LQRLESYRRI TSGKCPQKAV IFKTKLAKDI CADPKKKWVQ DSMKYLDQKS PTPKP

Chemokine (C-C motif) ligand 11 (CCL11) is a small cytokine belonging to the CC chemokine family that is also known as eotaxin. CCL11 selectively recruits eosinophils by inducing their chemotaxis, and therefore, is implicated in allergic responses. The effects of CCL11 are mediated by its binding to a G-protein-linked receptor known as a chemokine receptor. Chemokine receptors for which CCL11 is a ligand include CCR2, CCR3 and CCR5. The gene for human CCL11 (scya11) is encoded on three exons and is located on chromosome 17.

Eotaxin His Tag Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 74 amino acids fragment (24-87) corresponding to the mature Eotaxin protein and having a molecular mass of 8345.9 Dalton with an amino-terminal hexahistidine tag.The Eotaxin-His is purified by proprietary chromatographic techniques.

UniProt Protein Function:CCL11: In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3. Belongs to the intercrine beta (chemokine CC) family.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: extracellular region; extracellular space; intracellular

Molecular Function:CCR chemokine receptor binding; chemokine activity; protein binding

Biological Process: actin filament organization; cell adhesion; cellular calcium ion homeostasis; chemotaxis; chronic inflammatory response; cytoskeleton organization and biogenesis; eosinophil chemotaxis; G-protein coupled receptor protein signaling pathway; inflammatory response; lymphocyte chemotaxis; mast cell chemotaxis; monocyte chemotaxis; neutrophil chemotaxis; positive regulation of actin filament polymerization; positive regulation of angiogenesis; positive regulation of cell migration; positive regulation of endothelial cell proliferation; positive regulation of GTPase activity; positive regulation of inflammatory response; protein amino acid phosphorylation; regulation of cell shape; response to radiation; response to virus; signal transduction

Disease: Asthma, Susceptibility To; Human Immunodeficiency Virus Type 1, Susceptibility To

NCBI Summary:This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. [provided by RefSeq, Sep 2014]
UniProt Code:P51671
NCBI GenInfo Identifier:1706661
NCBI Gene ID:6356
NCBI Accession:P51671.1
UniProt Secondary Accession:P51671,P50877, Q92490, Q92491,
UniProt Related Accession:P51671
Molecular Weight:10,732 Da
NCBI Full Name:Eotaxin
NCBI Synonym Full Names:C-C motif chemokine ligand 11
NCBI Official Symbol:CCL11��
NCBI Official Synonym Symbols:SCYA11��
NCBI Protein Information:eotaxin
UniProt Protein Name:Eotaxin
UniProt Synonym Protein Names:C-C motif chemokine 11; Eosinophil chemotactic protein; Small-inducible cytokine A11
Protein Family:Eotaxin
UniProt Gene Name:CCL11��
UniProt Entry Name:CCL11_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P51671
Research Area:
Chemokines
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