Chemokines Recombinant Proteins

Human Eotaxin 3 Recombinant Protein (RPPB1130)

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SKU:
RPPB1130
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9Y258
Research Area:
Chemokines

Description

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Product Name:Human Eotaxin 3 Recombinant Protein
Product Code:RPPB1130
Size:50µg
Species:Human
Target:Eotaxin 3
Synonyms:C-C motif chemokine 26, Small-inducible cytokine A26, Eotaxin-3, Macrophage inflammatory protein 4-alpha, MIP-4-alpha, Thymic stroma chemokine-1, TSC-1, CC chemokine IMAC, CCL26, SCYA26, IMAC, MIP-4a, MGC126714, MIP-4alpha.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The Eotaxin-3 solution contains Phosphate Buffered Saline pH7.4 and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MTRGSDISKT CCFQYSHKPL PWTWVRSYEF TSNSCSQRAV IFTTKRGKKV CTHPRKKWVQ KYISLLKTPK QL

Eotaxin-3 (CCL26) is a small cytokine that belongs to the CC chemokine family also known as TARC (thymus and activation regulated chemokine). CCL26 is major eotaxin produced and released by alveolar epithelial cells which is involved in autoregulation of CCR3 receptors and other eotaxins. Eotaxin-3 is involved in immunoregulatory and inflammatory processes. Eotaxin-3 specifically binds and stimulates chemotaxis in T cells and elicits its effects by interacting with the chemokine receptor CCR4. CCL26 exhibits chemotactic activity for normal peripheral blood eosinophils and basophils. Eotaxin-3 may play a part in the eosinophil accumulation in atopic diseases. Eotaxin-3 is overexpressed in eosinophilic esophagitis, and the expression level correlates with disease severity. Eotaxin-3 is expressed constitutively in thymus, but only briefly in phytohemagglutinin-stimulated peripheral blood mononuclear cells. CCL26 is one of two Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 7.

Eotaxin-3 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 72 amino acids (24-94 a.a.) and having a total molecular mass of 8.5kDa. Eotaxin-3 is purified by proprietary chromatographic techniques.

UniProt Protein Function:CCL26: Chemotactic for eosinophils and basophils. Binds to CCR3. Belongs to the intercrine beta (chemokine CC) family.
UniProt Protein Details:

Protein type:Chemokine; Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 7q11.23

Cellular Component: extracellular space

Molecular Function:chemokine activity

Biological Process: cell-cell signaling; positive regulation of actin filament polymerization; positive regulation of endothelial cell proliferation; immune response; chemotaxis; signal transduction; inflammatory response; positive regulation of cell migration

NCBI Summary:This gene is one of two Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 7. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for normal peripheral blood eosinophils and basophils. The product of this gene is one of three related chemokines that specifically activate chemokine receptor CCR3. This chemokine may contribute to the eosinophil accumulation in atopic diseases. [provided by RefSeq, Jul 2008]
UniProt Code:Q9Y258
NCBI GenInfo Identifier:6685990
NCBI Gene ID:10344
NCBI Accession:Q9Y258.1
UniProt Secondary Accession:Q9Y258,Q52LV8, A0N0Q5,
UniProt Related Accession:Q9Y258
Molecular Weight:
NCBI Full Name:C-C motif chemokine 26
NCBI Synonym Full Names:chemokine (C-C motif) ligand 26
NCBI Official Symbol:CCL26��
NCBI Official Synonym Symbols:IMAC; TSC-1; MIP-4a; SCYA26; MIP-4alpha��
NCBI Protein Information:C-C motif chemokine 26; eotaxin-3; MIP-4-alpha; chemokine N1; CC chemokine IMAC; thymic stroma chemokine-1; small inducible cytokine A26; small-inducible cytokine A26; macrophage inflammatory protein 4-alpha; small inducible cytokine subfamily A (Cys-Cys), member 26
UniProt Protein Name:C-C motif chemokine 26
UniProt Synonym Protein Names:CC chemokine IMAC; Eotaxin-3; Macrophage inflammatory protein 4-alpha; MIP-4-alpha; Small-inducible cytokine A26; Thymic stroma chemokine-1; TSC-1
Protein Family:C-C motif chemokine
UniProt Gene Name:CCL26��
UniProt Entry Name:CCL26_HUMAN
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