CD Antigens Recombinant Proteins

Human ENTPD6 Recombinant Protein (RPPB3450)

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SKU:
RPPB3450
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O75354
Research Area:
CD Antigens

Description

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Product Name:Human ENTPD6 Recombinant Protein
Product Code:RPPB3450
Size:20µg
Species:Human
Target:ENTPD6
Synonyms:ectonucleoside triphosphate diphosphohydrolase 6 isoform 1, CD39L2, dJ738P15.3, IL-6SAG, IL6ST2, NTPDase-6.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:ENTPD6 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 10% glycerol and 0.4M urea.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 80.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSKWHRATA TQAFFSITRA APGARWGQQA HSPLGTAADG HEVFYGIMFD AGSTGTRVHV FQFTRPPRET PTLTHETFKA LKPGLSAYAD DVEKSAQGIR ELLDVAKQDI PFDFWKATPL VLKATAGLRL LPGEKAQKLL QKVKEVFKAS PFLVGDDCVS IMNGTDEGVS AWITINFLTG SLKTPGGSSV GMLDLGGGST QIAFLPRVEG TLQASPPGYL TALRMFNRTY KLYSYSYLGL GLMSARLAIL GGVEGQPAKD GKELVSPCLS PSFKGEWEHA EVTYRVSGQK AAASLHELCA ARVSEVLQNR VHRTEEVKHV DFYAFSYYYD LAAGVGLIDA EKGGSLVVGD FEIAAKYVCR TLETQPQSSP FSCMDLTYVS LLLQEFGFPR SKVLKLTRKI DNVETSWALG AIFHYIDSLN RQKSPAS

Ectonucleoside Triphosphate Diphosphohydrolase 6 or ENTPD6 is an enzyme, akin to E-type nucleotidases. E-type nucleotidases, for instance CD39, are responsible for extracellular nucleotides catabolism. ENTPD6 has four apyrase-conserved areas like all to E-type nucleotidases. Rather spliced transcript agents that codes various isoforms were discovered for the DNA segment.

ENTPD6 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 447amino acids (61-484a.a.) and having a molecular mass of 48.7kDa.ENTPD6 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:ENTPD6: Might support glycosylation reactions in the Golgi apparatus and, when released from cells, might catalyze the hydrolysis of extracellular nucleotides. Hydrolyzes preferentially nucleoside 5'-diphosphates, nucleoside 5'-triphosphates are hydrolyzed only to a minor extent, there is no hydrolysis of nucleoside 5'-monophosphates. The order of activity with different substrates is GDP > IDP >> UDP = CDP >> ADP. Belongs to the GDA1/CD39 NTPase family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Nucleotide Metabolism - pyrimidine; Nucleotide Metabolism - purine; Membrane protein, integral; Hydrolase; EC 3.6.1.6

Chromosomal Location of Human Ortholog: 20p11.21

Cellular Component: Golgi membrane; extracellular space; cell surface; integral to membrane; plasma membrane

Molecular Function:nucleoside-triphosphatase activity; guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity; uridine-diphosphatase activity

Biological Process: response to magnesium ion; metabolic process; response to calcium ion

NCBI Summary:ENTPD6 is similar to E-type nucleotidases (NTPases). NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD6 contains 4 apyrase-conserved regions which is characteristic of NTPases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:O75354
NCBI GenInfo Identifier:317373443
NCBI Gene ID:955
NCBI Accession:O75354.3
UniProt Secondary Accession:O75354,Q5QPJ2, Q5QPJ5, Q7Z5B5, Q8N3H3, Q8TAS7, Q9UJD1 A6NCX6, D3DW49,
UniProt Related Accession:O75354
Molecular Weight:53,118 Da
NCBI Full Name:Ectonucleoside triphosphate diphosphohydrolase 6
NCBI Synonym Full Names:ectonucleoside triphosphate diphosphohydrolase 6 (putative)
NCBI Official Symbol:ENTPD6��
NCBI Official Synonym Symbols:CD39L2; IL6ST2; IL-6SAG; NTPDase-6; dJ738P15.3��
NCBI Protein Information:ectonucleoside triphosphate diphosphohydrolase 6; CD39 antigen-like 2; CD39-like 2; HCV-E2 binding protein 1; NTPDase 6; ectonucleoside triphosphate diphosphohydrolase 6 (putative function); interleukin 6 signal transducer-2
UniProt Protein Name:Ectonucleoside triphosphate diphosphohydrolase 6
UniProt Synonym Protein Names:CD39 antigen-like 2
Protein Family:Ectonucleoside triphosphate diphosphohydrolase
UniProt Gene Name:ENTPD6��
UniProt Entry Name:ENTP6_HUMAN
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