Enzymes Recombinant Proteins

Human ENO2 Recombinant Protein (RPPB1615)

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SKU:
RPPB1615
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P09104
Research Area:
Enzymes

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Human ENO2 Recombinant Protein
Product Code:RPPB1615
Size:10µg
Species:Human
Target:ENO2
Synonyms:Gamma-enolase, EC 4.2.1.11, 2-phospho-D-glycerate hydro-lyase, Neural enolase, Neuron-specific enolase, NSE, Enolase 2, ENO2.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:Enolase 2 is supplied in 10mM Tris-HCl (pH 8), 250mM NaCl, 0.5mM DTT, 1.5mM Cysteine, and 50% Glycerol.
Stability:Store at 4°C if entire vial will be used within 1-2 weeks. Store, frozen at -20°C for longer periods of time. Please prevent freeze-thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE. Single band on Western Blot.

NSE is expressed primarily in neurons, in normal and neoplastic neuroendocrine cells. NSE is a highly soluble cytoplasmic protein that is readily secreted into the CSF and serum following tissue damage. NSE shows neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons and binds in a calcium-dependent manner to cultured neocortical neurons promoting cell survival.

Neuron Specific Enolase Human Recombinant is expressed in E. coli containing 433 amino acids 2-434 fused to an amino terminal hexahistidine tag.The NSE is purified by proprietary chromatographic techniques.

UniProt Protein Function:ENO2: an enzyme with 2-phospho-D-glycerate hydro-lyase activity. One of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates.
UniProt Protein Details:

Protein type:Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 4.2.1.11; Lyase

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: cytosol; extracellular space; myelin sheath; perikaryon; phosphopyruvate hydratase complex; photoreceptor inner segment; plasma membrane

Molecular Function:magnesium ion binding; phosphopyruvate hydratase activity; protein binding

Biological Process: carbohydrate metabolic process; gluconeogenesis; glucose metabolic process

NCBI Summary:This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates. [provided by RefSeq, Jul 2008]
UniProt Code:P09104
NCBI GenInfo Identifier:20981682
NCBI Gene ID:2026
NCBI Accession:P09104.3
UniProt Secondary Accession:P09104,Q96J33, B7Z2X9,
UniProt Related Accession:P09104
Molecular Weight:42,707 Da
NCBI Full Name:Gamma-enolase
NCBI Synonym Full Names:enolase 2 (gamma, neuronal)
NCBI Official Symbol:ENO2��
NCBI Official Synonym Symbols:NSE; HEL-S-279��
NCBI Protein Information:gamma-enolase
UniProt Protein Name:Gamma-enolase
UniProt Synonym Protein Names:2-phospho-D-glycerate hydro-lyase; Enolase 2; Neural enolase; Neuron-specific enolase; NSE
Protein Family:Gamma-enolase
UniProt Gene Name:ENO2��
UniProt Entry Name:ENOG_HUMAN
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system_update_altDatasheetHuman NSE/ENO2 Recombinant Protein Gamma-enolase; also known as Enolase 2; belongs to the enolase family. The alpha/alpha homodimer of ENO2 is expressed in embryo and in