Human EMCN Recombinant Protein (RPPB3445)
- SKU:
- RPPB3445
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9ULC0
Description
| Product Name: | Human EMCN Recombinant Protein |
| Product Code: | RPPB3445 |
| Size: | 10µg |
| Species: | Human |
| Target: | EMCN |
| Synonyms: | Endomucin, Endomucin-2, Gastric cancer antigen Ga34, Mucin-14, MUC-14, EMCN, EMCN2, MUC14. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | EMCN protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer, pH8.0, 10% glycerol, 1mM DTT and 100mM NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMNSTGV LEAANNSLVV TTTKPSITTP NTESLQKNVV TPTTGTTPKG TITNELLKMS LMSTATFLTS KDEGLKATTT DVRKNDSIIS NVTVTSVTLP NAVSTLQSSK PKTETQSSIK TTEIPGSVLQ PDASPSKTGT LTSIPVTIPE NTSQSQVIGT EGGKNASTSA TSRSYSS |
Endothelial sialomucin (Endomucin) interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix. Endomucin is expressed in the heart, kidney and lung.
EMCN Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 197 amino acids (19-190 a.a) and having a molecular mass of 20.5kDa.EMCN is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | EMCN: Endothelial sialomucin, also called endomucin or mucin- like sialoglycoprotein, which interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell adhesion; Membrane protein, integral Chromosomal Location of Human Ortholog: 4q24 Cellular Component: integral to membrane; plasma membrane; extracellular region |
| NCBI Summary: | EMCN is a mucin-like sialoglycoprotein that interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix (Kinoshita et al., 2001 [PubMed 11418125]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q9ULC0 |
| NCBI GenInfo Identifier: | 229576885 |
| NCBI Gene ID: | 51705 |
| NCBI Accession: | NP_001153166.1 |
| UniProt Secondary Accession: | Q9ULC0,Q8NEY5, Q8WWE7, Q9NRM8, A8K716, B4E347, |
| UniProt Related Accession: | Q9ULC0 |
| Molecular Weight: | 27,452 Da |
| NCBI Full Name: | endomucin isoform 2 |
| NCBI Synonym Full Names: | endomucin |
| NCBI Official Symbol: | EMCN�� |
| NCBI Official Synonym Symbols: | EMCN2; MUC14�� |
| NCBI Protein Information: | endomucin; MUC-14; mucin-14; endomucin-2; gastric cancer antigen Ga34 |
| UniProt Protein Name: | Endomucin |
| UniProt Synonym Protein Names: | Endomucin-2; Gastric cancer antigen Ga34; Mucin-14; MUC-14 |
| Protein Family: | Endomucin |
| UniProt Gene Name: | EMCN�� |
| UniProt Entry Name: | MUCEN_HUMAN |
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