Human ELP4 Recombinant Protein (RPPB3442)

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SKU:
RPPB3442
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q96EB1

Description

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Product Name:Human ELP4 Recombinant Protein
Product Code:RPPB3442
Size:20µg
Species:Human
Target:ELP4
Synonyms:Elongator complex protein 4, ELP4, Elongator Acetyltransferase Complex Subunit 4, hELP4, PAX6 neighbor gene protein, C11orf19, PAXNEB, dJ68P15A.1, PAX6NEB.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:ELP4 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 80.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMAAVATC GSVAASTGSA VATASKSNVT SFQRRGPRAS VTNDSGPRLV SIAGTRPSVR NGQLLVSTGL PALDQLLGGG LAVGTVLLIE EDKYNIYSPL LFKYFLAEGI VNGHTLLVAS AKEDPANILQ ELPAPLLDDK CKKEFDEDVY NHKTPESNIK MKIAWRYQLL PKMEIGPVSS SRFGHYYDAS KRMPQELIEA SNWHGFFLPE KISSTLKVEP CSLTPGYTKL LQFIQNIIYE EGFDGSNPQK KQRNILRIGI QNLGSPLWGD DICCAENGGN SHSLTKFLYV LRGLLRTSLS ACIITMPTHL IQNKAIIARV TTLSDVVVGL ESFIGSERET NPLYKDYHGL IHIRQIPRLN NLICDESDVK DLAFKLKRKL FTIERLHLPP DLSDTVSRSS KMDLAESAKR LGPGCGMMAG GKKHLDF

ElongatorAcetyltransferase Complex Subunit 4, also known as ELP4 is a protein codinggene which is a subunit of the RNA polymerase IIelongator complex. ELP4 complements phenotypes of yeast ELP4 deletionmutants and is related to Rolandicepilepsy.

ELP4 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 447 amino acids (1-424 a.a.) and having a molecular mass of 49kDa.ELP4 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:ELP4: Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Belongs to the ELP4 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Unknown functionChromosomal Location of Human Ortholog: 11p13Cellular Component: nucleoplasm; transcription elongation factor complex; Elongator holoenzyme complex; cytoplasm; histone acetyltransferase complexMolecular Function: protein binding; histone acetyltransferase activity; phosphorylase kinase regulator activityBiological Process: regulation of transcription from RNA polymerase II promoter; establishment and/or maintenance of chromatin architecture; RNA elongation from RNA polymerase II promoter; regulation of protein kinase activityDisease: Aniridia
UniProt Protein Details:
NCBI Summary:This gene encodes a component of the six subunit elongator complex, a histone acetyltransferase complex that associates directly with RNA polymerase II during transcriptional elongation. The human gene can partially complement sensitivity phenotypes of yeast ELP4 deletion mutants. This gene has also been associated with Rolandic epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
UniProt Code:Q96EB1
NCBI GenInfo Identifier:570359562
NCBI Gene ID:26610
NCBI Accession:NP_001275654.1
UniProt Secondary Accession:Q96EB1,Q9H4E8, Q9NX11, B4E3W0, E7EPZ6
UniProt Related Accession:Q96EB1
Molecular Weight:52,765 Da
NCBI Full Name:elongator complex protein 4 isoform 2
NCBI Synonym Full Names:elongator acetyltransferase complex subunit 4
NCBI Official Symbol:ELP4��
NCBI Official Synonym Symbols:AN; hELP4; PAXNEB; PAX6NEB; C11orf19; dJ68P15A.1��
NCBI Protein Information:elongator complex protein 4
UniProt Protein Name:Elongator complex protein 4
UniProt Synonym Protein Names:PAX6 neighbor gene protein
Protein Family:Elongator complex protein
UniProt Gene Name:ELP4��
UniProt Entry Name:ELP4_HUMAN
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