Human ELAVL2 Recombinant Protein (RPPB3439)

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SKU:
RPPB3439
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q12926

Description

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Product Name:Human ELAVL2 Recombinant Protein
Product Code:RPPB3439
Size:20µg
Species:Human
Target:ELAVL2
Synonyms:ELAV Like Neuron-Specific RNA Binding Protein 2, HUB, ELAV(Embryonic Lethal, Abnormal Vision, Drosophila)-Like 2 (Hu Antigen B), NervousSystem-Specific RNA-Binding Protein Hel-N1, Hu-Antigen B, HELN1, ELAV(Embryonic Lethal, Abnormal Vision, Drosophila)-Like 2, ELAV-Like NeuronalProtein 1 Isoform Hel-N2, ELAV-Like Neuronal Protein 1, ELAV-Like Protein 2, HuAntigen B, HEL-N1, ELAV-like protein 2, ELAV-like neuronal protein 1, Hu-antigenB.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:ELAVL2 protein solution (0.5mg/ml) containing Phosphatebuffered saline (pH7.4), 30% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMETQLSN GPTCNNTANG PTTINNNCSS PVDSGNTEDS KTNLIVNYLP QNMTQEELKS LFGSIGEIES CKLVRDKITG QSLGYGFVNY IDPKDAEKAI NTLNGLRLQT KTIKVSYARP SSASIRDANL YVSGLPKTMT QKELEQLFSQ YGRIITSRIL VDQVTGISRG VGFIRFDKRI EAEEAIKGLN GQKPPGATEP ITVKFANNPS QKTNQAILSQ LYQSPNRRYP GPLAQQAQRF RFSPMTIDGM TSLAGINIPG HPGTGWCIFV YNLAPDADES ILWQMFGPFG AVTNVKVIRD FNTNKCKGFG FVTMTNYDEA AMAIASLNGY RLGDRVLQVS FKTNKTHKA

ELAV Like Neuron-Specific RNA Binding Protein 2, also known asELAVL2� is a neural-specific RNA-bindingprotein which is recognized �with hisability to bind to several 3' UTRs,� aswell as its own and in addition those of FOS and ID. ELAVL2 identify a GAAAmotif in the RNA. One of the diseases associated with ELAVL2 is contagiouspustular dermatitis.

ELAVL2 Human Recombinant produced in E.Coli is a single, non-glycosylatedpolypeptide chain containing 369 amino acids (1-346 a.a) and having a molecularmass of 40.4kDa.ELAVL2 is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.

UniProt Protein Function:ELAVL2: Binds RNA. Seems to recognize a GAAA motif. Can bind to its own 3'-UTR, the FOS 3'-UTR and the ID 3'-UTR. Belongs to the RRM elav family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:RNA-binding

Chromosomal Location of Human Ortholog: 9p21.3

Cellular Component: nucleoplasm

Molecular Function:mRNA 3'-UTR binding; protein binding; RNA binding

Biological Process: nuclear mRNA splicing, via spliceosome; regulation of transcription, DNA-dependent

NCBI Summary:The protein encoded by this gene is a neural-specific RNA-binding protein that is known to bind to several 3' UTRs, including its own and also that of FOS and ID. The encoded protein may recognize a GAAA motif in the RNA. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
UniProt Code:Q12926
NCBI GenInfo Identifier:93141258
NCBI Gene ID:1993
NCBI Accession:Q12926.2
UniProt Secondary Accession:Q12926,Q13235, Q59G15, Q8NEM4, Q9H1Q8, D3DRK3,
UniProt Related Accession:Q12926
Molecular Weight:40kDa
NCBI Full Name:ELAV-like protein 2
NCBI Synonym Full Names:ELAV like RNA binding protein 2
NCBI Official Symbol:ELAVL2��
NCBI Official Synonym Symbols:HUB; HELN1; HEL-N1��
NCBI Protein Information:ELAV-like protein 2
UniProt Protein Name:ELAV-like protein 2
UniProt Synonym Protein Names:ELAV-like neuronal protein 1; Hu-antigen B; HuB; Nervous system-specific RNA-binding protein Hel-N1
Protein Family:ELAV-like protein
UniProt Gene Name:ELAVL2��
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