Human EIF5A2 Recombinant Protein (RPPB3438)
- SKU:
- RPPB3438
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9GZV4
Description
| Product Name: | Human EIF5A2 Recombinant Protein |
| Product Code: | RPPB3438 |
| Size: | 10µg |
| Species: | Human |
| Target: | EIF5A2 |
| Synonyms: | eIF-5A-2, EIF-5A2, eIF5AII, Eukaryotic translation initiation factor 5A-2, Eukaryotic initiation factor 5A isoform 2, EIF5A2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | EIF5A2 Human solution containing 20mM Tris-HCl pH-8 & 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MADEIDFTTG DAGASSTYPM QCSALRKNGF VVLKGRPCKI VEMSTSKTGK HGHAKVHLVG IDIFTGKKYE DICPSTHNMD VPNIKRNDYQ LICIQDGYLS LLTETGEVRE DLKLPEGELG KEIEGKYNAG EDVQVSVMCA MSEEYAVAIK PCK |
EIF5A2 is part of the eukaryotic initiation factor 5A subfamily, is an vital protein strongly linked to cellular polyamine homeostasis. EIF5A2 promotes the formation of the first peptide bond during the initial stage of protein synthesis. EIF5A2 is the single eukaryotic protein to have a hypusine residue, which is a post-translational modification of a lysine by the addition of a butylamino group.
EIF5A2 Recombinant E.coli produced in E.Coli is a single, non-glycosylated polypeptide chain containing 173 amino acids (1-153 a.a.) and having a molecular mass of 18.9 kDa. The EIF5A2 is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | EIF5A2: mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. Belongs to the eIF-5A family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 3q26.2 Cellular Component: cytosol; intracellular membrane-bound organelle Molecular Function:protein binding Biological Process: hypusine biosynthetic process from peptidyl-lysine; positive regulation of cell proliferation |
| UniProt Code: | Q9GZV4 |
| NCBI GenInfo Identifier: | 74762725 |
| NCBI Gene ID: | 56648 |
| NCBI Accession: | Q9GZV4.3 |
| UniProt Secondary Accession: | Q9GZV4,B2R4V5, |
| UniProt Related Accession: | Q9GZV4 |
| Molecular Weight: | 16,793 Da |
| NCBI Full Name: | Eukaryotic translation initiation factor 5A-2 |
| NCBI Synonym Full Names: | eukaryotic translation initiation factor 5A2 |
| NCBI Official Symbol: | EIF5A2�� |
| NCBI Official Synonym Symbols: | EIF-5A2; eIF5AII�� |
| NCBI Protein Information: | eukaryotic translation initiation factor 5A-2 |
| UniProt Protein Name: | Eukaryotic translation initiation factor 5A-2 |
| UniProt Synonym Protein Names: | Eukaryotic initiation factor 5A isoform 2 |
| UniProt Gene Name: | EIF5A2�� |
| UniProt Entry Name: | IF5A2_HUMAN |
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