Human EIF3I Recombinant Protein (RPPB3426)
- SKU:
- RPPB3426
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q13347
Description
| Product Name: | Human EIF3I Recombinant Protein |
| Product Code: | RPPB3426 |
| Size: | 20µg |
| Species: | Human |
| Target: | EIF3I |
| Synonyms: | Eukaryotic Translation Initiation Factor 3, Subunit I, EIF3S2,Eukaryotic Translation Initiation Factor 3, Subunit 2 Beta, 36kDa, EukaryoticTranslation Initiation Factor 3 Subunit 2, TRIP-1, eIF-3-beta, EIF3 P36, TGF-BetaReceptor-Interacting Protein 1, PRO2242, eIF3-beta, eIF3-p36, EukaryoticTranslation Initiation Factor 3 Subunit I, Eukaryotic Translation InitiationFactor 3, Subunit 2 (Beta, 36kD), Predicted Protein Of HQ2242, TGFbetaReceptor-Interacting Protein 1, eIF3i. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | APOBEC4 protein solution (1mg/ml) containing 20mMTris-HCl buffer (pH 8.0), 0.4M UREA and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMKPILLQ GHERSITQIK YNREGDLLFT VAKDPIVNVW YSVNGERLGTYMGHTGAVWC VDADWDTKHV LTGSADNSCR LWDCETGKQL ALLKTNSAVR TCGFDFGGNI IMFSTDKQMGYQCFVSFFDL RDPSQIDNNE PYMKIPCNDS KITSAVWGPL GECIIAGHES GELNQYSAKS GEVLVNVKEH SRQINDIQLS RDMTMFVTASKDNTAKLFDS TTLEHQKTFR TERPVNSAAL SPNYDHVVLG GGQEAMDVTT TSTRIGKFEA RFFHLAFEEEFGRVKGHFGP INSVAFHPDG KSYSSGGEDG YVRIHYFDPQ YFEFEFEA |
Eukaryotictranslation initiation factor 3, subunit I (EIF3I) is part of the eukaryotictranslation initiation factor 3 (eIF-3) complex, which is essential fornumerous steps in the initiation of protein synthesis. The eIF-3 complex linkswith the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP: methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43SPIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanningof the mRNA for AUG recognition. The eIF-3 complex is also essential fordisassembly and recycling of post-termination ribosomal complexes andsubsequently prevents premature joining of the 40S and 60S ribosomal subunitsprior to initiation. Among the diseases associated with EIF3I are clonorchiasis,and tonsillitis.
EIF3I Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 348 amino acids (1-325aa) and having a molecular mass of 38.9kDa.EIF3I is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | eIF3-beta: eukaryotic translation initiation factor 3 subunit 2. Binds to the 40S ribosome and promotes the binding of methionyl-tRNAi and mRNA. eIF-3 is composed of at least 12 different subunits. Phosphorylated by TGF-beta type II receptor. |
| UniProt Protein Details: | Protein type:Translation; Translation initiation Chromosomal Location of Human Ortholog: 1p34.1 Cellular Component: eukaryotic translation initiation factor 3 complex; cytosol Molecular Function:protein binding; translation initiation factor activity Biological Process: cellular protein metabolic process; translation; translational initiation; gene expression; formation of translation preinitiation complex; regulation of translational initiation |
| UniProt Code: | Q13347 |
| NCBI GenInfo Identifier: | 2494895 |
| NCBI Gene ID: | 8668 |
| NCBI Accession: | Q13347.1 |
| UniProt Related Accession: | Q13347 |
| Molecular Weight: | 325 |
| NCBI Full Name: | Eukaryotic translation initiation factor 3 subunit I |
| NCBI Synonym Full Names: | eukaryotic translation initiation factor 3, subunit I |
| NCBI Official Symbol: | EIF3I�� |
| NCBI Official Synonym Symbols: | TRIP1; EIF3S2; TRIP-1; PRO2242; eIF3-p36; eIF3-beta�� |
| NCBI Protein Information: | eukaryotic translation initiation factor 3 subunit I; EIF3I; eIF3 p36; eIF-3-beta; predicted protein of HQ2242; TGFbeta receptor-interacting protein 1; TGF-beta receptor-interacting protein 1; eukaryotic translation initiation factor 3 subunit 2; eukaryotic translation initiation factor 3, subunit 2 beta, 36kDa |
| UniProt Protein Name: | Eukaryotic translation initiation factor 3 subunit I |
| UniProt Synonym Protein Names: | Eukaryotic translation initiation factor 3 subunit 2; TGF-beta receptor-interacting protein 1; eIF3 p36 |
| UniProt Gene Name: | EIF3I�� |
| UniProt Entry Name: | EIF3I_HUMAN |
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