Human EIF2AK3 / PERK ELISA Kit

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SKU:
HUFI01038
Product Type:
ELISA Kit
Size:
96 Assays
Uniprot:
Q9NZJ5
Sensitivity:
0.188ng/ml
Range:
0.313-20ng/ml
ELISA Type:
Sandwich
Synonyms:
EIF2AK3, eukaryotic translation initiation factor 2 alpha kinase 3, eukaryotic translation initiation factor 2-alpha kinase 3, Pancreatic eIF2-alpha kinase, PRKR-like endoplasmic reticulum kinase
Reactivity:
Human
Research Area:
Metabolism

Description

Human EIF2AK3 / PERK ELISA Kit

EIF2AK3/PERK phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, inactivating it and causing a rapid reduction of translational initiation and transcription. It's been discovered that EIF2AK3/PERK impacts mitochondrial function. It's a type I membrane protein found in the ER, where it is induced by ER stress caused on damaged proteins. The EIF2AK3/PERK gene has mutations that are linked to Wolcott-Rallison syndrome. EIF2AK3 is a susceptibility factor for epiphyseal dysplasia, early-onset diabetes mellitus and permanent neonatal diabetes mellitus.

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