Human EIF1AY Recombinant Protein (RPPB3421)

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SKU:
RPPB3421
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O14602

Description

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Product Name:Human EIF1AY Recombinant Protein
Product Code:RPPB3421
Size:10µg
Species:Human
Target:EIF1AY
Synonyms:Eukaryotic translation initiation factor 1A Y chromosome, Eukaryotic translation initiation factor 4C, eIF-4C, eIF-1A Y isoform.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The EIF1AY protein solution (0.5mg/1ml) is formulated in 20 mM Tris-HCl buffer (pH8.0), 0.1M NaCl, 1mM DTT and 20% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.Please avoid freeze thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMPKNKGK GGKNRRRGKN ENESEKRELV FKEDGQEYAQ VIKMLGNGRL EALCFDGVKR LCHIRGKLRK KVWINTSDII LVGLRDYQDN KADVILKYNA DEARSLKAYG ELPEHAKINE TDTFGPGDDD EIQFDDIGDD DEDIDDI

EIF1AY is comparable to eukaryotic translation initiation factor 1A (EIF1A). EIF1AY protein is essential for highest rate of protein biosynthesis. EIF1AY increases ribosome dissociation into subunits and is obligatory for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5' end of capped RNA.

EIF1AY produced in E.Coli is a single, non-glycosylated polypeptide chain containing�167 amino acids (1-144.a.a) and having a molecular mass of 18.8kDa. EIF1AY is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:EIF1AY: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. Belongs to the eIF-1A family.
UniProt Protein Details:

Protein type:Translation initiation; Translation

Chromosomal Location of Human Ortholog: Yq11.223

Molecular Function:protein binding; translation initiation factor activity

Biological Process: translational initiation

NCBI Summary:This gene is located on the non-recombining region of the Y chromosome. It encodes a protein related to eukaryotic translation initiation factor 1A (EIF1A), which may function in stabilizing the binding of the initiator Met-tRNA to 40S ribosomal subunits. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
UniProt Code:O14602
NCBI GenInfo Identifier:25014072
NCBI Gene ID:9086
NCBI Accession:O14602.4
UniProt Secondary Accession:O14602,Q9BS77,
UniProt Related Accession:O14602
Molecular Weight:16,442 Da
NCBI Full Name:Eukaryotic translation initiation factor 1A, Y-chromosomal
NCBI Synonym Full Names:eukaryotic translation initiation factor 1A, Y-linked
NCBI Official Symbol:EIF1AY��
NCBI Official Synonym Symbols:eIF-4C��
NCBI Protein Information:eukaryotic translation initiation factor 1A, Y-chromosomal; eIF-1A Y isoform; eukaryotic translation initiation factor 1A, Y chromosome; eukaryotic translation initiation factor 4C
UniProt Protein Name:Eukaryotic translation initiation factor 1A, Y-chromosomal
UniProt Synonym Protein Names:Eukaryotic translation initiation factor 4C; eIF-4C
Protein Family:Eukaryotic translation initiation factor
UniProt Gene Name:EIF1AY��
UniProt Entry Name:IF1AY_HUMAN
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