Human EIF1AX Recombinant Protein (RPPB3420)
- SKU:
- RPPB3420
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P47813
Description
| Product Name: | Human EIF1AX Recombinant Protein |
| Product Code: | RPPB3420 |
| Size: | 20µg |
| Species: | Human |
| Target: | EIF1AX |
| Synonyms: | eukaryotic translation initiation factor 1A, X-linked, eIF-4C, EIF1A, EIF4C, eIF-1A, EIF1AP1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The EIF1AX protein solution (1mg/1ml) contains 20mM Tris-HCl buffer (pH8.0) containing 5mM DTT, 200mM NaCl and 40% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MPKNKGKGGK NRRRGKNENE SEKRELVFKE DGQEYAQVIK MLGNGRLEAM CFDGVKRLCH IRGKLRKKVW INTSDIILVG LRDYQDNKAD VILKYNADEA RSLKAYGELP EHAKINETDT FGPGDDDEIQ FDDIGDDDED IDDI |
EIF1AX is an important eukaryotic translation initiation factor. EIF1AX is essential for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5'' end of capped RNA. EIF1AP1 is needed for maximal rate of protein biosynthesis. EIF1AX increases ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA (I) to 40 S ribosomal subunits.
EIF1AX Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 150 amino acids (1-144a.a.) and having a molecular wieght of 18.6kDa. EIF1AX is fused to 20a.a. His-Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | EIF1AX: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. Belongs to the eIF-1A family |
| UniProt Protein Details: | Protein type:Translation initiation; RNA-binding; Translation Chromosomal Location of Human Ortholog: Xp22.12 Cellular Component: cytosol Molecular Function:protein binding; translation factor activity, nucleic acid binding; translation initiation factor activity Biological Process: cellular protein metabolic process; translation; translational initiation; gene expression |
| NCBI Summary: | This gene encodes an essential eukaryotic translation initiation factor. The protein is required for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5' end of capped RNA. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P47813 |
| NCBI GenInfo Identifier: | 1352425 |
| NCBI Gene ID: | 1964 |
| NCBI Accession: | P47813.2 |
| UniProt Secondary Accession: | P47813,Q0VGC2, Q5JPS5, Q5JPS6, B2R5U5, |
| UniProt Related Accession: | P47813 |
| Molecular Weight: | Calculated: 16kDaObserved: 16kDa |
| NCBI Full Name: | Eukaryotic translation initiation factor 1A, X-chromosomal |
| NCBI Synonym Full Names: | eukaryotic translation initiation factor 1A, X-linked |
| NCBI Official Symbol: | EIF1AX�� |
| NCBI Official Synonym Symbols: | EIF1A; EIF4C; eIF-1A; eIF-4C; EIF1AP1�� |
| NCBI Protein Information: | eukaryotic translation initiation factor 1A, X-chromosomal; eIF-1A X isoform; eukaryotic translation initiation factor 4C; Putative eukaryotic translation initiation factor 1A; eukaryotic translation initiation factor 1A, X chromosome |
| UniProt Protein Name: | Eukaryotic translation initiation factor 1A, X-chromosomal |
| UniProt Synonym Protein Names: | Eukaryotic translation initiation factor 4C; eIF-4C |
| Protein Family: | Eukaryotic translation initiation factor |
| UniProt Gene Name: | EIF1AX�� |
| UniProt Entry Name: | IF1AX_HUMAN |
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