Human EHF Recombinant Protein (RPPB3418)
- SKU:
- RPPB3418
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9NZC4
Description
| Product Name: | Human EHF Recombinant Protein |
| Product Code: | RPPB3418 |
| Size: | 10µg |
| Species: | Human |
| Target: | EHF |
| Synonyms: | ESE3, ESE3B, ESEJ, ETS homologous factor, hEHF, ETS domain-containing transcription factor, Epithelium-specific Ets transcription factor 3, EHF. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The EHF solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMILEGGG VMNLNPGNNL LHQPPAWTDS YSTCNVSSGF FGGQWHEIHP QYWTKYQVWE WLQHLLDTNQ LDANCIPFQE FDINGEHLCS MSLQEFTRAA GTAGQLLYSN LQHLKWNGQC SSDLFQSTHN VIVKTEQTEP SIMNTWKDEN YLYDTNYGST VDLLDSKTFC RAQISMTTTS HLPVAESPDM KKEQDPPAKC HTKKHNPRGT HLWEFIRDIL LNPDKNPGLI KWEDRSEGVF RFLKSEAVAQ LWGKKKNNSS MTYEKLSRAM RYYYKREILE RVDGRRLVYK FGKNARGWRE NEN |
ETS homologous factor (EHF) is a part of the ESE subfamily of Ets transcription factors. Ets factors are an important kind of transcriptional regulators which take part in hema-topoiesis, angiogenesis, organogenesis, oncogenesis and specification of neuronal connectivity. EHF is expressed solely in a subset of epithelial cells, with highest expression noticed in glandular epithelium of the prostate, pancreas, salivary gland and trachea. EHF transactivates the c-Met promoter via 3 high affinity binding sites, which support the notion that EHF contribute to branching morphogenesis.
EHF Human Recombinant produced in E. coli is a single polypeptide chain containing 323 amino acids (1-300) and having a molecular mass of 37.3kDa. EHF is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | EHF: Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation. May act as a repressor for a specific subset of ETS/AP-1-responsive genes and as a modulator of the nuclear response to mitogen- activated protein kinase signaling cascades. Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through Ets- binding sequences on the TNFRSF10B/DR5 promoter. May contribute to development and carcinogenesis by acting as a tumor suppressor gene or anti-oncogene. Belongs to the ETS family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 11p12 Cellular Component: nucleoplasm; Golgi apparatus; nucleus Molecular Function:DNA binding; transcription factor activity Biological Process: transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; cell proliferation; epithelial cell differentiation; multicellular organismal development; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | This gene encodes a protein that belongs to an ETS transcription factor subfamily characterized by epithelial-specific expression (ESEs). The encoded protein acts as a transcriptional repressor and may be involved in epithelial differentiation and carcinogenesis. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011] |
| UniProt Code: | Q9NZC4 |
| NCBI GenInfo Identifier: | 74762761 |
| NCBI Gene ID: | 26298 |
| NCBI Accession: | Q9NZC4.1 |
| UniProt Secondary Accession: | Q9NZC4,Q9H509, Q9UKF9, Q9Y5V4, Q9Y5V5, D3DR08, D3DR10 E9PSB2, |
| UniProt Related Accession: | Q9NZC4 |
| Molecular Weight: | 37,356 Da |
| NCBI Full Name: | ETS homologous factor |
| NCBI Synonym Full Names: | ets homologous factor |
| NCBI Official Symbol: | EHF�� |
| NCBI Official Synonym Symbols: | ESE3; ESEJ; ESE3B�� |
| NCBI Protein Information: | ETS homologous factor; EHF; hEHF; ESE3 transcription factor; ETS domain-containing transcription factor; epithelium-specific Ets transcription factor 3 |
| UniProt Protein Name: | ETS homologous factor |
| UniProt Synonym Protein Names: | ETS domain-containing transcription factor; Epithelium-specific Ets transcription factor 3; ESE-3 |
| Protein Family: | ETS homologous factor |
| UniProt Gene Name: | EHF�� |
| UniProt Entry Name: | EHF_HUMAN |
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