Immunology Recombinant Proteins
Human EGFR/ErbB1 Recombinant Protein (RPES3165)
- SKU:
- RPES3165
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Immunology
Description
Human EGFR/ErbB1 Recombinant Protein
EGFR is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK; PI3 kinase-AKT; PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16; activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling.
| Product Name: | Human EGFR/ErbB1 Recombinant Protein (RPES3165) |
| Product Code: | RPES3165 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | Human Cells |
| Synonyms: | Epidermal growth factor receptor, EGFR, Proto-oncogene c-ErbB-1, Receptortyrosine-protein kinase erbB-1, EGFR |
| Accession: | P00533 |
| Sequence: | Leu25-Ser645 |
| Fusion tag: | C-Fc |
| Activity: | Immobilized Human EGF(Cat: PKSH033687) at 10µg/ml(100 ?l/well) can bind Human EGFR-Fc. |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human Epidermal Growth Factor Receptor is produced by our Mammalian expression system and the target gene encoding Leu25-Ser645 is expressed with a Fc tag at the C-terminus. |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 95.7 kDa |
| AP Mol Mass: | 130 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of PBS; pH7.4. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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