Human EGFR/ErbB1 Recombinant Protein (RPES2136)
- SKU:
- RPES2136
- Product Type:
- Recombinant Protein
- Species:
- Human
Description
Human EGFR/ErbB1 Recombinant Protein
As a member of the epidermal growth factor receptor (EGFR) family; EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF; amphiregulin; TGF-α; betacellulin; etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation; survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization; the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK; PI3K/PKB and STAT). In addition; EGFR signaling also has been shown to exert action on carcinogenesis and disease progression; and thus EGFR protein is proposed as a target for cancer therapy currently.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
| Product Name: | Human EGFR/ErbB1 Recombinant Protein (RPES2136) |
| Product Code: | RPES2136 |
| Size: | 20µg |
| Species: | Human |
| Expressed Host: | Baculovirus-Insect cells |
| Synonyms: | ERBB,ERBB1,HER1,mENA,NISBD2,PIG61 |
| Accession: | NP_005219 |
| Sequence: | Met 668-Ala 1210 |
| Fusion tag: | N-His-GST |
| Activity: | The specific activity was determined to be 105 nmol/min/mg using Poly(Glu:Tyr) 4:1 as substrate. |
| Endotoxin: | <1.0 EU per µg of the protein as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the cytoplasmic domain (Met 668-Ala 1210) of human EGFR (NP_005219) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus. |
| Purity: | > 85 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 89.1 kDa |
| Formulation: | Supplied as sterile 20 mM Tris; 500 mM NaCl; 10 % glycerol; pH 7.4 |
| Shipping: | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt; store it immediately at<-20°C. |
| Stability and Storage: | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
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