Human EFNA3 Recombinant Protein (RPPB3407)
- SKU:
- RPPB3407
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P52797
Description
| Product Name: | Human EFNA3 Recombinant Protein |
| Product Code: | RPPB3407 |
| Size: | 20µg |
| Species: | Human |
| Target: | EFNA3 |
| Synonyms: | Ephrin-A3, EFL2, Ehk1-L, EPLG3, LERK3, EPH-related receptor tyrosine kinase ligand 3. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | EFNA3 protein solution (1mg/ml) containing 20mM Tris-HClbuffer (pH 8.0), 0.4M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMQGPGG ALGNRHAVYW NSSNQHLRRE GYTVQVNVND YLDIYCPHYNSSGVGPGAGP GPGGGAEQYV LYMVSRNGYR TCNASQGFKR WECNRPHAPH SPIKFSEKFQ RYSAFSLGYEFHAGHEYYYI STPTHNLHWK CLRMKVFVCC ASTSHSGEKPVPTLPQFTMG PNVKINVLED FEGENPQVPK LEKSISG |
EFNA3belongs to the ephrin (EPH) family. The ephrins and EPH-related receptors includethe largestsubfamily of receptor protein-tyrosine kinases which have been implicated inmediating developmental events, especially in the nervous system and in erythropoiesis.Ephrins are divided into the ephrin-A (EFNA) class and the ephrin-B (EFNB)class, based on their structures and sequence relationships. TheEphrins from the EFNA class are anchored to the membrane by a glycosylphosphatidylinositol linkage, whilethe others from the EFNB class are transmembrane proteins.
EFNA3 Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 217 amino acids (23-214 a.a) andhaving a molecular mass of 24kDa. EFNA3 is fused to a 25 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.
| UniProt Protein Function: | EFNA3: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Belongs to the ephrin family. |
| UniProt Protein Details: | Protein type:Ligand, receptor tyrosine kinase; Cell development/differentiation; Membrane protein, GPI anchor Chromosomal Location of Human Ortholog: 1q21-q22 Cellular Component: integral to plasma membrane; extracellular region; plasma membrane Molecular Function:ephrin receptor binding; transmembrane-ephrin receptor activity Biological Process: axon guidance; cell-cell signaling; ephrin receptor signaling pathway |
| NCBI Summary: | This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P52797 |
| NCBI GenInfo Identifier: | 1706671 |
| NCBI Gene ID: | 1944 |
| NCBI Accession: | P52797.1 |
| UniProt Secondary Accession: | P52797,Q0VGC9, Q5SR70, B7ZAD3, D3DV85, |
| UniProt Related Accession: | P52797 |
| Molecular Weight: | 23,575 Da |
| NCBI Full Name: | Ephrin-A3 |
| NCBI Synonym Full Names: | ephrin-A3 |
| NCBI Official Symbol: | EFNA3�� |
| NCBI Official Synonym Symbols: | EFL2; EPLG3; LERK3; Ehk1-L�� |
| NCBI Protein Information: | ephrin-A3; EFL-2; EHK1 ligand; LERK-3; eph-related receptor tyrosine kinase ligand 3; ligand of eph-related kinase 3 |
| UniProt Protein Name: | Ephrin-A3 |
| UniProt Synonym Protein Names: | EFL-2; EHK1 ligand; EHK1-L; EPH-related receptor tyrosine kinase ligand 3; LERK-3 |
| Protein Family: | Ephrin |
| UniProt Gene Name: | EFNA3�� |
| UniProt Entry Name: | EFNA3_HUMAN |
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