Human EDN / Eosinophil derived neurotoxin ELISA Kit

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SKU:
HUFI02407
Product Type:
ELISA Kit
Size:
96 Assays
Uniprot:
P10153
Sensitivity:
0.375ng/ml
Range:
0.625-40ng/ml
ELISA Type:
Sandwich
Synonyms:
EDN, Eosinophil-Derived Neurotoxin, RNASE2, EDN, RNS2, Non-secretory ribonuclease, Ribonuclease US, Ribonuclease 2, RNase 2, Eosinophil-derived neurotoxin, RNase UpI-2
Reactivity:
Human
Research Area:
Cell Biology

Description

Human EDN / Eosinophil derived neurotoxin ELISA Kit

EDN (Eosinophil derived neurotoxin) is a highly potent and selective eosinophil-derived neurotoxin (EDNT) that is isolated from the venom of the Brazilian sand spider, Loxosceles intermedia. EDN is composed of a disulfide-linked heterodimer of the 33-kDa light chain and the 11.5-kDa heavy chain of eosinophil granule proteins. The LC has high affinity for voltage-gated sodium channels and blocks their inactivation, leading to neuronal hyperexcitability and cell death. The HC binds to apoptotic cells and inhibits the release of mitochondrial cytochrome c into the cytosol, thereby blocking apoptosis. EDNT is a potent neurotoxin that blocks voltage-gated sodium channels, causing neuronal hyperexcitability and cell death.

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