Human EDA2R Recombinant Protein (RPPB3391)
- SKU:
- RPPB3391
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9HAV5
Description
| Product Name: | Human EDA2R Recombinant Protein |
| Product Code: | RPPB3391 |
| Size: | 10µg |
| Species: | Human |
| Target: | EDA2R |
| Synonyms: | Tumor necrosis factor receptor superfamily member 27, X-linked ectodysplasin-A2 receptor, EDA-A2 receptor, Ectodysplasin A2 Receptor, X-Linked Ectodysplasin-A2 Receptor, EDA-A2 Receptor, TNFRSF27, XEDAR, Tumor Necrosis Factor Receptor Superfamily Member XEDAR, Tumor Necrosis Factor Receptor Superfamily Member 27, Ectodysplasin A2 Isoform Receptor, EDA-A2R, EDAA2R. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | EDA2R protein solution (0.5mg/ml) contains Phosphate Buffered Saline (pH 7.4), 20% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | ADPMDCQENE YWDQWGRCVT CQRCGPGQEL SKDCGYGEGG DAYCTACPPR RYKSSWGHHR CQSCITCAVI NRVQKVNCTA TSNAVCGDCL PRFYRKTRIG GLQDQECIPC TKQTPTSEVQ CAFQLSLVEA DAPTVPPQEA TLEPKSCDKT HTCPPCPAPE LLGGPSVFLF PPKPKDTLMI SRTPEVTCVV VDVSHEDPEV KFNWYVDGVE VHNAKTKPRE EQYNSTYRVV SVLTVLHQDW LNGKEYKCKV SNKALPAPIE KTISKAKGQP REPQVYTLPP SRDELTKNQV SLTCLVKGFY PSDIAVEWES NGQPENNYKT TPPVLDSDGS FFLYSKLTVD KSRWQQGNVF SCSVMHEALH NHYTQKSLSL SPGKHHHHHH |
EDA2R (ectodysplasin A2 receptor) mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated through binding to TRAF3 and TRAF6. In addition, Mutations in EDA give rise to a clinical syndrome characterized by loss of hair, sweat glands, and teeth. EDA2R specifically binds to EDA-A2 isoform. This protein is a type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily, and contains 3 cysteine-rich repeats and a single transmembrane domain however it lacks an N-terminal signal peptide. Alternatively spliced transcript variants have been found for this gene. Among the diseases associated with EDA2R are ectodermal dysplasia 1, hypohidrotic, x-linked, and hypohidrotic ectodermal dysplasia.
EDA2R Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 380 amino acids (1-138a.a.) and having a molecular mass of 42.5kDa (Molecular size on SDS-PAGE will appear at approximately 40-57kDa). EDA2R is expressed with a 242 amino acid hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6. |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily, and contains cysteine-rich repeats and a single transmembrane domain. This protein binds to the EDA-A2 isoform of ectodysplasin, which plays an important role in maintenance of hair and teeth. Alternatively spliced transcript variants encodes distinct protein isoforms. [provided by RefSeq, Apr 2016] |
| UniProt Code: | Q9HAV5 |
| NCBI GenInfo Identifier: | 313104030 |
| NCBI Gene ID: | 60401 |
| NCBI Accession: | Q9HAV5.2 |
| UniProt Secondary Accession: | Q9HAV5,Q5VYX9, Q5VYY0, Q6UWM2, Q8IZA6 |
| UniProt Related Accession: | Q9HAV5 |
| Molecular Weight: | 32,959 Da |
| NCBI Full Name: | Tumor necrosis factor receptor superfamily member 27 |
| NCBI Synonym Full Names: | ectodysplasin A2 receptor |
| NCBI Official Symbol: | EDA2R�� |
| NCBI Official Synonym Symbols: | XEDAR; EDAA2R; EDA-A2R; TNFRSF27�� |
| NCBI Protein Information: | tumor necrosis factor receptor superfamily member 27 |
| UniProt Protein Name: | Tumor necrosis factor receptor superfamily member 27 |
| UniProt Synonym Protein Names: | X-linked ectodysplasin-A2 receptor; EDA-A2 receptor |
| Protein Family: | Tumor necrosis factor receptor superfamily |
| UniProt Gene Name: | EDA2R�� |
| UniProt Entry Name: |
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