Human EDA2R Recombinant Protein (RPPB3390)
- SKU:
- RPPB3390
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9HAV5
Description
| Product Name: | Human EDA2R Recombinant Protein |
| Product Code: | RPPB3390 |
| Size: | 20µg |
| Species: | Human |
| Target: | EDA2R |
| Synonyms: | Ectodysplasin A2 Receptor, XEDAR, TNFRSF27, EDA-A2 Receptor, X-Linked Ectodysplasin-A2 Receptor, EDAA2R, EDA-A2R, Tumor Necrosis Factor Receptor Superfamily Member 27, Tumor Necrosis Factor Receptor Superfamily Member XEDAR, EDAR2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | EDA2R protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMDCQENE YWDQWGRCVT CQRCGPGQEL SKDCGYGEGG DAYCTACPPRRYKSSWGHHR CQSCITCAVI NRVQKVNCTA TSNAVCGDCL PRFYRKTRIG GLQDQECIPC TKQTPTSEVQCAFQLSLVEA DAPTVPPQEA T |
EDA2R (ectodysplasin A2 receptor) mediates the activation of theNF-kappa-B and JNK pathways. Activation seems to be mediated through binding toTRAF3 and TRAF6. In addition, Mutations in EDA give rise to a clinical syndromecharacterized by loss of hair, sweat glands, and teeth. EDA2R specificallybinds to EDA-A2 isoform. This protein is a type III transmembrane protein ofthe TNFR (tumor necrosis factor receptor) superfamily, and contains 3cysteine-rich repeats and a single transmembrane domain however it lacks anN-terminal signal peptide. Alternatively spliced transcript variants have been foundfor this gene. Among the diseases associated with EDA2R are ectodermaldysplasia 1, hypohidrotic, x-linked, and hypohidrotic ectodermal dysplasia.
EDA2R Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 161 amino acids (1-138 a.a) and having a molecular mass of 17.7kDa.EDA2R is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6. |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily, and contains cysteine-rich repeats and a single transmembrane domain. This protein binds to the EDA-A2 isoform of ectodysplasin, which plays an important role in maintenance of hair and teeth. Alternatively spliced transcript variants encodes distinct protein isoforms. [provided by RefSeq, Apr 2016] |
| UniProt Code: | Q9HAV5 |
| NCBI GenInfo Identifier: | 313104030 |
| NCBI Gene ID: | 60401 |
| NCBI Accession: | Q9HAV5.2 |
| UniProt Secondary Accession: | Q9HAV5,Q5VYX9, Q5VYY0, Q6UWM2, Q8IZA6 |
| UniProt Related Accession: | Q9HAV5 |
| Molecular Weight: | 32,959 Da |
| NCBI Full Name: | Tumor necrosis factor receptor superfamily member 27 |
| NCBI Synonym Full Names: | ectodysplasin A2 receptor |
| NCBI Official Symbol: | EDA2R�� |
| NCBI Official Synonym Symbols: | XEDAR; EDAA2R; EDA-A2R; TNFRSF27�� |
| NCBI Protein Information: | tumor necrosis factor receptor superfamily member 27 |
| UniProt Protein Name: | Tumor necrosis factor receptor superfamily member 27 |
| UniProt Synonym Protein Names: | X-linked ectodysplasin-A2 receptor; EDA-A2 receptor |
| Protein Family: | Tumor necrosis factor receptor superfamily |
| UniProt Gene Name: | EDA2R�� |
| UniProt Entry Name: |
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