Enzymes Recombinant Proteins
Human ECHS1 Recombinant Protein (RPPB1606)
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- SKU:
- RPPB1606
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P30084
- Research Area:
- Enzymes
Description
| Product Name: | Human ECHS1 Recombinant Protein |
| Product Code: | RPPB1606 |
| Size: | 20µg |
| Species: | Human |
| Target: | ECHS1 |
| Synonyms: | Enoyl-CoA hydratase 1, SCEH. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The ECHS1 protein solution (1mg/ml) contains 20mM Tris-HCl buffer (pH-8), 1mM DTT,0.1M NaCl and 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MASGANFEYI IAEKRGKNNT VGLIQLNRPK ALNALCDGLI DELNQALKIF EEDPAVGAIV LTGGDKAFAA GADIKEMQNL SFQDCYSSKF LKHWDHLTQV KKPVIAAVNG YAFGGGCELA MMCDIIYAGE KAQFAQPEIL IGTIPGAGGT QRLTRAVGKS LAMEMVLTGD RISAQDAKQA GLVSKICPVE TLVEEAIQCA EKIASNSKIV VAMAKESVNA AFEMTLTEGS KLEKKLFYST FATDDRKEGM TAFVEKRKAN FKDQ |
ECHS1 is part of the hydratase/isomerase superfamily. ECHS1 is localized in the mitochondrial matrix and Expressed in muscle, liver and fibroblasts, with low expression in kidney and spleen, ECHS1 exists as a homohexamer that takes part in the second phase of the mitochondrial fatty acid Beta-oxidation pathway.
ECHS1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 284 amino acids (28-290 a.a.) and having a molecular mass of 30.6kDa.ECHS1 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate. Has high substrate specificity for crotonyl-CoA and moderate specificity for acryloyl-CoA, 3-methylcrotonyl-CoA and methacrylyl-CoA. It is noteworthy that binds tiglyl-CoA, but hydrates only a small amount of this substrate. |
| NCBI Summary: | The protein encoded by this gene functions in the second step of the mitochondrial fatty acid beta-oxidation pathway. It catalyzes the hydration of 2-trans-enoyl-coenzyme A (CoA) intermediates to L-3-hydroxyacyl-CoAs. The gene product is a member of the hydratase/isomerase superfamily. It localizes to the mitochondrial matrix. Transcript variants utilizing alternative transcription initiation sites have been described in the literature. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P30084 |
| NCBI GenInfo Identifier: | 62906863 |
| NCBI Gene ID: | 1892 |
| NCBI Accession: | P30084.4 |
| UniProt Secondary Accession: | P30084,O00739, Q5VWY1, Q96H54, |
| UniProt Related Accession: | P30084 |
| Molecular Weight: | 31,387 Da |
| NCBI Full Name: | Enoyl-CoA hydratase, mitochondrial |
| NCBI Synonym Full Names: | enoyl-CoA hydratase, short chain 1 |
| NCBI Official Symbol: | ECHS1�� |
| NCBI Official Synonym Symbols: | SCEH; ECHS1D�� |
| NCBI Protein Information: | enoyl-CoA hydratase, mitochondrial |
| UniProt Protein Name: | Enoyl-CoA hydratase, mitochondrial |
| UniProt Synonym Protein Names: | Enoyl-CoA hydratase 1; Short-chain enoyl-CoA hydratase; SCEH |
| Protein Family: | Enoyl-CoA hydratase |
| UniProt Gene Name: | ECHS1�� |
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