Human DYNLL1 Recombinant Protein (RPPB3379)
- SKU:
- RPPB3379
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P63167
Description
| Product Name: | Human DYNLL1 Recombinant Protein |
| Product Code: | RPPB3379 |
| Size: | 20µg |
| Species: | Human |
| Target: | DYNLL1 |
| Synonyms: | PIN, DLC1, DLC8, DNCL1, DNCLC1, Dynein Light Chain LC8-type 1, Dynein Cytoplasmic Light polypeptide 1, Protein Inhibitor of Neuronal Nitric Oxide Synthase |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The DYNLL1 protein solution (1mg/1ml) is formulated in 20mM Tris-HCl buffer (pH8.0) 0.2M NaCl, 1mM DTT and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.�Store, frozen at -20°C for longer periods of time.Please avoid freeze thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MCDRKAVIKN ADMSEEMQQD SVECATQALE KYNIEKDIAA HIKKEFDKKY NPTWHCIVGR NFGSYVTHET KHFIYFYLGQ VAILLFKSG |
DYNLL1 is a protein that cooperates with NOS1 causing NOS1 inhibition. Binding of DYNLL1 weakens NOS1 (Neuronal nitric oxide synthase) dimer, a conformation needed for activity, and it regulates several biologic processes through its effects on nitric oxide synthase activity. DYNLL1 is a ubiquitously expressed protein that demonstrates high expression in testis and moderate expression in brain.
DYNLL1 Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 109 amino acids (1-89a.a.) and having a molecular mass of 12.5kDa. The DYNLL1 is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | LC8: a highly conserved cytoplasmic protein of the dynein light chain family. Cytoplasmic dyneins are large enzyme complexes. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain. Interacts with and inhibits the activity of neuronal nitric oxide synthase (nNOS). A highly conserved protein, showing 92% amino acid similarity with the nematode homolog. Binding of this protein destabilizes the nNOS dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. |
| UniProt Protein Details: | Protein type:Microtubule-binding; Motility/polarity/chemotaxis; Motor Chromosomal Location of Human Ortholog: 12q24.23 Cellular Component: kinetochore; signalosome; microtubule; centrosome; membrane; cytoplasmic dynein complex; mitochondrion; cytoplasm; plasma membrane; nucleus; cytosol Molecular Function:protein C-terminus binding; protein domain specific binding; protein binding; enzyme binding; protein homodimerization activity; nitric-oxide synthase regulator activity; motor activity Biological Process: anatomical structure morphogenesis; viral reproduction; transcription, DNA-dependent; apoptosis; organelle organization and biogenesis; antigen processing and presentation of exogenous peptide antigen via MHC class II; female gamete generation; microtubule-based process; substantia nigra development; regulation of transcription, DNA-dependent; transport; regulation of catalytic activity; negative regulation of phosphorylation; mitotic cell cycle; actin cytoskeleton organization and biogenesis; G2/M transition of mitotic cell cycle |
| NCBI Summary: | Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P63167 |
| NCBI GenInfo Identifier: | 52783578 |
| NCBI Gene ID: | 8655 |
| NCBI Accession: | P63167.1 |
| UniProt Secondary Accession: | P63167,Q15701, |
| UniProt Related Accession: | P63167 |
| Molecular Weight: | 89 |
| NCBI Full Name: | Dynein light chain 1, cytoplasmic |
| NCBI Synonym Full Names: | dynein, light chain, LC8-type 1 |
| NCBI Official Symbol: | DYNLL1�� |
| NCBI Official Synonym Symbols: | LC8; PIN; DLC1; DLC8; LC8a; DNCL1; hdlc1; DNCLC1�� |
| NCBI Protein Information: | dynein light chain 1, cytoplasmic; 8 kDa dynein light chain; cytoplasmic dynein light polypeptide; dynein, cytoplasmic, light polypeptide 1; protein inhibitor of neuronal nitric oxide synthase |
| UniProt Protein Name: | Dynein light chain 1, cytoplasmic |
| UniProt Synonym Protein Names: | 8 kDa dynein light chain; DLC8; Dynein light chain LC8-type 1; Protein inhibitor of neuronal nitric oxide synthase; PIN |
| UniProt Gene Name: | DYNLL1�� |
| UniProt Entry Name: | DYL1_HUMAN |
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