Enzymes Recombinant Proteins

Human DUSP6 Recombinant Protein (RPPB1590)

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RPPB1590

Description

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Product Name:Human DUSP6 Recombinant Protein
Product Code:RPPB1590
Size:10µg
Species:Human
Target:DUSP6
Synonyms:Dual specificity protein phosphatase 6, Dual specificity protein phosphatase PYST1, Mitogen-activated protein kinase phosphatase 3, MAP kinase phosphatase 3, MKP-3, DUSP6, MKP3, PYST1, Dual Specificity Phosphatase 6, Dual specificity phosphatase 6 isoform a.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:DUSP6 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MIDTLRPVPF ASEMAISKTV AWLNEQLELG NERLLLMDCR PQELYESSHI ESAINVAIPG IMLRRLQKGN LPVRALFTRG EDRDRFTRRC GTDTVVLYDE SSSDWNENTG GESVLGLLLK KLKDEGCRAF YLEGGFSKFQ AEFSLHCETN LDGSCSSSSP PLPVLGLGGL RISSDSSSDI ESDLDRDPNS ATDSDGSPLS NSQPSFPVEI LPFLYLGCAK DSTNLDVLEE FGIKYILNVT PNLPNLFENA GEFKYKQIPI SDHWSQNLSQ FFPEAISFID EARGKNCGVL VHCLAGISRS VTVTVAYLMQ KLNLSMNDAY DIVKMKKSNI SPNFNFMGQL LDFERTLGLS SPCDNRVPAQ QLYFTTPSNQ NVYQVDSLQS T

Dual Specificity Phosphatase 6, also known as DUSP6 belongs to the dual specificity protein phosphatase subfamily. DUSP6 is a Protein coding gene which inactivates MAP kinases. Various members of the family of dual specificity phosphatases show diverse tissue distribution, subcellular localization, and different modes of inducibility of their expression by extracellular stimuli.

DUSP6 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 401 amino acids (1-381 a.a) and having a molecular mass of 44.4kDa.DUSP6 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:Inactivates MAP kinases. Has a specificity for the ERK family (PubMed:9858808). Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia.
NCBI Summary:The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2014]
UniProt Code:Q16828
NCBI GenInfo Identifier:108860971
NCBI Gene ID:1848
NCBI Accession:Q16828.2
UniProt Secondary Accession:Q16828,O75109, Q53Y75, Q9BSH6,
UniProt Related Accession:Q16828
Molecular Weight:26,468 Da
NCBI Full Name:Dual specificity protein phosphatase 6
NCBI Synonym Full Names:dual specificity phosphatase 6
NCBI Official Symbol:DUSP6��
NCBI Official Synonym Symbols:HH19; MKP3; PYST1��
NCBI Protein Information:dual specificity protein phosphatase 6
UniProt Protein Name:Dual specificity protein phosphatase 6
UniProt Synonym Protein Names:Dual specificity protein phosphatase PYST1; Mitogen-activated protein kinase phosphatase 3; MAP kinase phosphatase 3; MKP-3
Protein Family:Dual specificity protein phosphatase
UniProt Gene Name:DUSP6��
UniProt Entry Name:DUS6_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q16828
Research Area:
Enzymes
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