Enzymes Recombinant Proteins

Human DUSP21 Recombinant Protein (RPPB1596)

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SKU:
RPPB1596
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9H596
Research Area:
Enzymes

Description

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Product Name:Human DUSP21 Recombinant Protein
Product Code:RPPB1596
Size:10µg
Species:Human
Target:DUSP21
Synonyms:Dual specificity phosphatase 21, Low molecular weight dual specificity phosphatase 21, LMW-DSP21, BJ-HCC-26 tumor antigen, EC 3.1.3.16, EC 3.1.3.48.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The DUSP21 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 200mM NaCl, 2mM DTT and 20% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMTASAS SFSSSQGVQQ PSIYSFSQIT RSLFLSNGVA ANDKLLLSSN RITAIVNASV EVVNVFFEGI QYIKVPVTDA RDSRLYDFFD PIADLIHTID MRQGRTLLHC MAGVSRSASL CLAYLMKYHS MSLLDAHTWT KSRRPIIRPN NGFWEQLINY EFKLFNNNTV RMINSPVGNI PDIYEKDLRM MISM

DUSP21 is a member of the protein-tyrosine phosphatase family. DUSPs inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residuesb. DUSP21 is able to dephosphorylate single and diphosphorylated synthetic MAPK peptides, favoring the phosphotyrosine and diphosphorylated forms over phosphothreonine. DUSP21 is only expressed in testis where there are dephosphorylated phosphotyrosine residues in MAPK peptides.

DUSP21 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 214 amino acids (1-190) and having a molecular mass of 24.1kDa.DUSP21 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:DUSP21: Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.Protein type: EC 3.1.3.16; EC 3.1.3.48; Mitochondrial; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificityChromosomal Location of Human Ortholog: Xp11.4-p11.23Cellular Component: cytoplasm; mitochondrial matrix; nucleusMolecular Function: MAP kinase tyrosine/serine/threonine phosphatase activity; protein binding; protein tyrosine phosphatase activityBiological Process: inactivation of MAPK activity
UniProt Protein Details:
NCBI Summary:This gene encodes a member of the dual specificity phosphatase family, specifically the low molecular weight dual specificity phosphatase family. The encoded protein localizes to both the cytoplasm and the nucleus and functions to remove phosphate groups from phosphotyrosine and phosphothreonine residues.[provided by RefSeq, Mar 2009]
UniProt Code:Q9H596
NCBI GenInfo Identifier:225703077
NCBI Gene ID:63904
NCBI Accession:NP_071359.3
UniProt Secondary Accession:Q9H596,Q0VDA6, Q6IAJ6, Q6YDQ8
UniProt Related Accession:Q9H596
Molecular Weight:21,529 Da
NCBI Full Name:dual specificity protein phosphatase 21
NCBI Synonym Full Names:dual specificity phosphatase 21
NCBI Official Symbol:DUSP21��
NCBI Official Synonym Symbols:LMWDSP21��
NCBI Protein Information:dual specificity protein phosphatase 21
UniProt Protein Name:Dual specificity protein phosphatase 21
UniProt Synonym Protein Names:Low molecular weight dual specificity phosphatase 21; LMW-DSP21
Protein Family:Dual specificity phosphatase
UniProt Gene Name:DUSP21��
UniProt Entry Name:DUS21_HUMAN
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