Immunology Recombinant Proteins

Human DR6/TNFRSF21 Recombinant Protein (RPES2166)

(No reviews yet) Write a Review
SKU:
RPES2166
Product Type:
Recombinant Protein
Species:
Human
Research Area:
Immunology

Description

system_update_altDatasheet

Human DR6/TNFRSF21 Recombinant Protein

Tumor Necrosis Factor Receptor Superfamily Member 21 (TNFRSF21) is a type I transmembrane receptor that includes four extracellular cysteine-rich motifs and a cytoplasmic death domain. DR6 is highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. DR6 may activate NF-kappa-B and JNK to promote apoptosis and T-cell differentiation. In addition, DR6 binds with N-APP, which is released by the deprivation of Trophic-factor. It triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). DR6 is also expressed on the tumor cell lines and can be induced by TNF-?.

View AllClose

0 Reviews

View AllClose