Human DPY30 Recombinant Protein (RPPB3374)
- SKU:
- RPPB3374
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9C005
Description
| Product Name: | Human DPY30 Recombinant Protein |
| Product Code: | RPPB3374 |
| Size: | 20µg |
| Species: | Human |
| Target: | DPY30 |
| Synonyms: | Dpy-30 Homolog (C. Elegans), Dpy-30-Like Protein,Dpy-30L, Protein Dpy-30 Homolog, HDPY-30, Cps25, Saf19, Protein dpy-30 homolog. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | DPY30 protein solution (1mg/ml) containing 20mM Tris-HClbuffer (pH 8.0), 0.2M NaCl,30% glycerol and 2mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMEPEQML EGQTQVAENP HSEYGLTDNV ERIVENEKIN AEKSSKQKVDLQSLPTRAYL DQTVVPILLQ GLAVLAKERP PNPIEFLASY LLKNKAQFED RN |
DPY30 is implicated in the methylation of histone H3 at Lys-4, mainly trimethylation. Histone H3 Lys-4 methylation symbolize a specific tag for epigenetictranscriptional activation. DPY30 takes part in histone H3 acetylation. In ateratocarcinoma cell, DPY30 plays a critical role in retinoicacid-induced differentiation along the neural lineage, regulating geneinduction and H3 Lys-4 methylation at key developmental loci. DPY30 also playsan indirect or direct part in endosomal transport.
DPY30 Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 122 amino acids (1-99 a.a) andhaving a molecular mass of 13.6 kDa.DPY30 is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.
| UniProt Protein Function: | As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport. |
| NCBI Summary: | This gene encodes an integral core subunit of the SET1/MLL family of H3K4 methyltransferases. The encoded protein directly controls cell cycle regulators and plays an important role in the proliferation and differentiation of human hematopoietic progenitor cells. [provided by RefSeq, Mar 2016] |
| UniProt Code: | Q9C005 |
| NCBI GenInfo Identifier: | 14211889 |
| NCBI Gene ID: | 84661 |
| NCBI Accession: | NP_115963.1 |
| UniProt Secondary Accession: | Q9C005,D6W578, |
| UniProt Related Accession: | Q9C005 |
| Molecular Weight: | 11,250 Da |
| NCBI Full Name: | protein dpy-30 homolog isoform 1 |
| NCBI Synonym Full Names: | dpy-30, histone methyltransferase complex regulatory subunit |
| NCBI Official Symbol: | DPY30�� |
| NCBI Official Synonym Symbols: | Cps25; Saf19; HDPY-30�� |
| NCBI Protein Information: | protein dpy-30 homolog |
| UniProt Protein Name: | Protein dpy-30 homolog |
| UniProt Synonym Protein Names: | Dpy-30-like protein; Dpy-30L |
| Protein Family: | DPY30 domain-containing protein |
| UniProt Gene Name: | DPY30�� |
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