Human DOK4 Recombinant Protein (RPPB3368)

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RPPB3368

Description

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Product Name:Human DOK4 Recombinant Protein
Product Code:RPPB3368
Size:20µg
Species:Human
Target:DOK4
Synonyms:docking protein 4, Downstream of tyrosine kinase 4, IRS-5, IRS5.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:DOK4 protein solution (1mg/ml) contains 20mM Tris-HClbuffer (pH 8.0), 0.4M UREA and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMATNFSD IVKQGYVKMK SRKLGIYRRC WLVFRKSSSK GPQRLEKYPDEKSVCLRGCP KVTEISNVKC VTRLPKETKR QAVAIIFTDD SARTFTCDSE LEAEEWYKTL SVECLGSRLNDISLGEPDLL APGVQCEQTD RFNVFLLPCP NLDVYGECKL QITHENIYLW DIHNPRVKLV SWPLCSLRRY GRDATRFTFE AGRMCDAGEGLYTFQTQEGE QIYQRVHSAT LAIAEQHKRV LLEMEKNVRL LNKGTEHYSY PCTPTTMLPR SAYWHHITGSQNIAEASSYA GEGYGAAQAS SETDLLNRFI LLKPKPSQGD SSEAKTPSQ

Docking Protein 4(DOK4) is amember of the DOK family. DOK proteins are enzymatically inert adaptor orscaffolding proteins. The DOK proteins present a docking platform for the compilationof multimolecular signaling complexes. DOK4 serves in RET-mediated neuriteoutgrowth and has a positive role in activation of the MAP kinase pathway. DOK4is a putative link with downstream effectors of RET in neuronaldifferentiation. DOK4 is involved in the regulation of the immune responseinduced by T-cells.

DOK4 Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 349 amino acids (1-326 a.a) andhaving a molecular mass of 39.4kDa.DOK4 is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.

UniProt Protein Function:DOK4: docking proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in Ret-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of Ret in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells. Interacts with Ret and TIE2. Interaction with Ret is mediated through the PTB domain and requires phosphorylation of Ret Y1062.
UniProt Protein Details:

Protein type:Adaptor/scaffold; Cell development/differentiation

Chromosomal Location of Human Ortholog: 16q21

Molecular Function:protein binding; receptor signaling protein activity; insulin receptor binding

Biological Process: nervous system development; MAPKKK cascade; transmembrane receptor protein tyrosine kinase signaling pathway

UniProt Code:Q8TEW6
NCBI GenInfo Identifier:84029600
NCBI Gene ID:55715
NCBI Accession:Q8TEW6.2
UniProt Secondary Accession:Q8TEW6,O75209, Q9BTP2, Q9NVV3,
UniProt Related Accession:Q8TEW6
Molecular Weight:326
NCBI Full Name:Docking protein 4
NCBI Synonym Full Names:docking protein 4
NCBI Official Symbol:DOK4��
NCBI Protein Information:docking protein 4; IRS5; IRS-5; insulin receptor substrate 5; downstream of tyrosine kinase 4
UniProt Protein Name:Docking protein 4
UniProt Synonym Protein Names:Downstream of tyrosine kinase 4; Insulin receptor substrate 5; IRS-5; IRS5
Protein Family:Docking protein
UniProt Gene Name:DOK4��
UniProt Entry Name:DOK4_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q8TEW6
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