Human DNASE2 (Deoxyribonuclease-2-alpha) ELISA Kit (HUFI03469)

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SKU:
HUFI03469
Product Type:
ELISA Kit
Size:
96 Assays
Uniprot:
O00115
Sensitivity:
46.875pg/ml
Range:
78.125-5000pg/ml
ELISA Type:
Sandwich
Synonyms:
Acid DNase, Deoxyribonuclease 2 alpha, Deoxyribonuclease II alpha, DNase II alpha, DNASE2, DNASE2A, DNL, DNL2, Lysosomal DNase II
Reactivity:
Human

Description

Human DNASE2 (Deoxyribonuclease-2-alpha) ELISA Kit

DNASE2 (Deoxyribonuclease 2, Lysosomal) encoded protein is a lysosomal deoxyribonuclease that cleaves DNA at the 3' non-terminal phosphate of dsDNA. This enzyme is involved in the degradation of nuclear and mitochondrial DNA. Mutations in DNASE2 are associated with combined oxidative phosphorylation deficiency 9 (COXPD9), a mitochondrial disease characterized by lactic acidosis, hypotonia, and encephalopathy. An important paralog of tDNASE2 is DNASE2B.

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