Human DNAJC12 Recombinant Protein (RPPB5205)

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SKU:
RPPB5205
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9UKB3

Description

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Product Name:Human DNAJC12 Recombinant Protein
Product Code:RPPB5205
Size:10µg
Species:Human
Target:DNAJC12
Synonyms:DnaJ homolog subfamily C member 12, J domain-containing protein 1, DNAJC12, JDP1, RP11-57G10.2.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The DNAJC12 solution (0.5mg/ml) contains 20mM Tris-HCl buffer, pH8.0, 10% glycerol, 2mM DTT and 100mM NaCl.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMDAILN YRSEDTEDYY TLLGCDELSS VEQILAEFKV RALECHPDKH PENPKAVETF QKLQKAKEIL TNEESRARYD HWRRSQMSMP FQQWEALNDS VKTSMHWVVR GKKDLMLEES DKTHTTKMEN EECNEQRERK KEELASTAEK TEQKEPKPLE KSVSPQNSDS SGFADVNGWH LRFRWSKDAP SELLRKFRNY EI

DnaJ (Hsp40) Homolog, Subfamily C, Member 12 (DNAJC12) belongs to the DnaJ/Hsp40 family. DnaJ/Hsp40 family members are linked with complex assembly, protein folding, and export. DnaJ/Hsp40 proteins are extremely conserved throughout evolution and function as co-chaperones regulating protein folding, transport, translational initiation and gene expression. DnaJC12 has a role in protein folding and export and is believed to be involved in estrogen control and the development of breast cancer. DNAJC12 is expressed at high levels in the brain, heart, and testis, and at reduced levels in the kidney and stomach.

DNAJC12 Human Recombinant produced in E. coli is a single polypeptide chain containing 222 amino acids (1-198) and having a molecular mass of 26kDa (Molecular weight on SDS-PAGE will appear higher).DNAJC12 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:DNAJC12: 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Chaperone

Chromosomal Location of Human Ortholog: 10q22.1

NCBI Summary:This gene encodes a member of a subclass of the HSP40/DnaJ protein family. Members of this family of proteins are associated with complex assembly, protein folding, and export. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q9UKB3
NCBI GenInfo Identifier:41406094
NCBI Gene ID:56521
NCBI Accession:NP_957714.1
UniProt Secondary Accession:Q9UKB3,Q5JVQ1, Q9UKB2,
UniProt Related Accession:Q9UKB3
Molecular Weight:Calculated MW: 198aa,23 kDaObserved MW: 23 kDa
NCBI Full Name:dnaJ homolog subfamily C member 12 isoform b
NCBI Synonym Full Names:DnaJ (Hsp40) homolog, subfamily C, member 12
NCBI Official Symbol:DNAJC12��
NCBI Official Synonym Symbols:JDP1��
NCBI Protein Information:dnaJ homolog subfamily C member 12; J domain containing protein 1 (JDP1); J domain protein 1; j domain-containing protein 1
UniProt Protein Name:DnaJ homolog subfamily C member 12
UniProt Synonym Protein Names:J domain-containing protein 1
Protein Family:DnaJ homolog subfamily
UniProt Gene Name:DNAJC12��
UniProt Entry Name:DJC12_HUMAN
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