Human DnaJ Recombinant Protein (RPPB5199)

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SKU:
RPPB5199
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P25685

Description

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Product Name:Human DnaJ Recombinant Protein
Product Code:RPPB5199
Size:25µg
Species:Human
Target:DnaJ
Synonyms:HSP-40, HSP40, DnaJ, DNAJB1, HSPF1, Hdj1, DnaJ homolog subfamily B member 1, Heat shock 40 kDa protein 1, Heat shock protein 40, DnaJ protein homolog 1, HDJ-1, Sis1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The protein solution contains 20mM Tris-HCl (pH 8.0), 2mM DTT, 0.2mM PMSF and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGKDYYQTLG LARGASDEEI KRAYRRQALR YHPDKNKEPG AEEKFKEIAE AYDVLSDPRK REIFDRYGEE GLKGSGPSGG SGGGANGTSF SYTFHGDPHAMFAEFFGGRN PFDTFFGQRN GEEGMDIDDP FSGFPMGMGG FTNVNFGRSR SAQEPARKKQ DPPVTHDLRV SLEEIYSGCT KKMKISHKRL NPDGKSIRNE DKILTIEVKK GWKEGTKITF PKEGDQTSNN IPADIVFVLK DKPHNIFKRD GSDVIYPARI SLREALCGCT VNVPTLDGRT IPVVFKDVIR PGMRRKVPGE GLPLPKTPEK RGDLIIEFEV IFPERIPQTS RTVLEQVLPI

Human HSP40 (heat shock protein with molecular size of 40kDa) is one of the mammalian homologues of bacterial DnaJ heat shock protein and regulates cellular processes by aiding in the folding, transport and assembly. HSP40 protein contains the J-domain which controls interaction with the ATPase domain of DnaK.

HSP40 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain (aa 1-340) and fused to a 20 aa His Tag at N-terminus, containing a total of 360 amino acids and having a molecular mass of 40.2 kDa. The HSP40 is purified by proprietary chromatographic techniques.

UniProt Protein Function:Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP.
NCBI Summary:This gene encodes a member of the DnaJ or Hsp40 (heat shock protein 40 kD) family of proteins. DNAJ family members are characterized by a highly conserved amino acid stretch called the 'J-domain' and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. The encoded protein is a molecular chaperone that stimulates the ATPase activity of Hsp70 heat-shock proteins in order to promote protein folding and prevent misfolded protein aggregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
UniProt Code:P25685
NCBI GenInfo Identifier:1706473
NCBI Gene ID:3337
NCBI Accession:P25685.4
UniProt Secondary Accession:P25685,B4DX52,
UniProt Related Accession:P25685
Molecular Weight:340
NCBI Full Name:DnaJ homolog subfamily B member 1
NCBI Synonym Full Names:DnaJ (Hsp40) homolog, subfamily B, member 1
NCBI Official Symbol:DNAJB1��
NCBI Official Synonym Symbols:Hdj1; Sis1; HSPF1; Hsp40; RSPH16B��
NCBI Protein Information:dnaJ homolog subfamily B member 1; human DnaJ protein 1; dnaJ protein homolog 1; radial spoke 16 homolog B; heat shock 40 kDa protein 1
UniProt Protein Name:DnaJ homolog subfamily B member 1
UniProt Synonym Protein Names:DnaJ protein homolog 1; Heat shock 40 kDa protein 1; HSP40; Heat shock protein 40; Human DnaJ protein 1; hDj-1
Protein Family:DnaJ homolog subfamily
UniProt Gene Name:DNAJB1��
UniProt Entry Name:DNJB1_HUMAN
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