Enzymes Recombinant Proteins

Human DLST Recombinant Protein (RPPB1579)

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SKU:
RPPB1579
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P36957
Research Area:
Enzymes

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Human DLST Recombinant Protein
Product Code:RPPB1579
Size:10µg
Species:Human
Target:DLST
Synonyms:dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex), Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex, component E2, DLST, E2K, OGDC-E2, EC 2.3.1.61, EC 2.3.1.
Source:Sf9 Insect cells
Formulation:DLST (0.74mg/ml)�is supplied in 20mM HEPES buffer pH-8.0, 200mM NaCl and 20% glycerol.
Stability:Store DLST�at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�Avoid multiple freeze-thaw cycles.
Purity:DLST purity was found to be greater than 75% as determined by SDS-PAGE.

DLST catalyzes the general transformation of 2-oxoglutarate to succinyl-CoA and CO(2). DLST holds multiple copies of 3 enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).

DLST is a Full-length cDNA coding for the mature form of the human OGDC-E2 protein having a molecular mass of 42,301 Dalton (pH 6.3).DLST protein is fused to a hexa-histidine purification tag.

UniProt Protein Function:DLST: The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of 3 enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3). Forms a 24-polypeptide structural core with octahedral symmetry. Belongs to the 2-oxoacid dehydrogenase family.
UniProt Protein Details:

Protein type:Amino Acid Metabolism - lysine degradation; Transferase; Carbohydrate Metabolism - citrate (TCA) cycle; EC 2.3.1.61; Mitochondrial

Chromosomal Location of Human Ortholog: 14q24.3

Cellular Component: membrane; mitochondrial matrix; oxoglutarate dehydrogenase complex; nucleus

Molecular Function:dihydrolipoyllysine-residue succinyltransferase activity

Biological Process: cellular metabolic process; generation of precursor metabolites and energy; tricarboxylic acid cycle; L-lysine catabolic process to acetyl-CoA via saccharopine; lysine catabolic process

NCBI Summary:This gene encodes a mitochondrial protein that belongs to the 2-oxoacid dehydrogenase family. This protein is one of the three components (the E2 component) of the 2-oxoglutarate dehydrogenase complex that catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]
UniProt Code:P36957
NCBI GenInfo Identifier:317373578
NCBI Gene ID:1743
NCBI Accession:P36957.4
UniProt Secondary Accession:P36957,Q7LDY7, Q9BQ32,
UniProt Related Accession:P36957
Molecular Weight:48,755 Da
NCBI Full Name:Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
NCBI Synonym Full Names:dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
NCBI Official Symbol:DLST��
NCBI Official Synonym Symbols:DLTS��
NCBI Protein Information:dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial; E2K; OGDC-E2
UniProt Protein Name:Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
UniProt Synonym Protein Names:2-oxoglutarate dehydrogenase complex component E2; OGDC-E2; Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2K
Protein Family:Serine transporter
UniProt Gene Name:DLST��
UniProt Entry Name:ODO2_HUMAN
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