Human DKK2 Recombinant Protein (RPPB3358)
- SKU:
- RPPB3358
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9UBU2
Description
| Product Name: | Human DKK2 Recombinant Protein |
| Product Code: | RPPB3358 |
| Size: | 10µg |
| Species: | Human |
| Target: | DKK2 |
| Synonyms: | Dickkopf 2 homolog (Xenopus laevis), dickkopf related protein-2, hDkk-2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The DKK2 solution (0.25mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMKLNSIK SSLGGETPGQ AANRSAGMYQ GLAFGGSKKG KNLGQAYPCS SDKECEVGRY CHSPHQGSSA CMVCRRKKKR CHRDGMCCPS TRCNNGICIP VTESILTPHI PALDGTRHRD RNHGHYSNHD LGWQNLGRPH TKMSHIKGHE GDPCLRSSDC IEGFCCARHF WTKICKPVLH QGEVCTKQRK KGSHGLEIFQ RCDCAKGLSC KVWKDATYSS KARLHVCQKI |
Dickkopf-related protein 2 (DKK2) is a member of the dickkopf family, which has a vital role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In adults, Dkks are involved in bone formation and bone disease, cancer and Alzheimer disease. DKK2 contains 2 cysteine rich regions and is implicated in embryonic development through its interactions with the Wnt signaling pathway. DKK2 may function as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular environment and the presence of the co-factor kremen 2. DKK2 protein activity is also controlled by binding to the Wnt co-receptor LRP6 (LDL-receptor related protein 6).
DKK2 Human Recombinant produced in E. coli is a single polypeptide chain containing 250 amino acids (34-259) and having a molecular mass of 27.6 kDa.DKK2 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | DKK2: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Interacts with LRP5 and LRP6. Expressed in heart, brain, skeletal muscle and lung. Belongs to the dickkopf family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide; Inhibitor Chromosomal Location of Human Ortholog: 4q25 Cellular Component: extracellular space |
| NCBI Summary: | This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UBU2 |
| NCBI GenInfo Identifier: | 13124093 |
| NCBI Gene ID: | 27123 |
| NCBI Accession: | Q9UBU2.1 |
| UniProt Secondary Accession: | Q9UBU2,Q9UIU3, A0AVE9, B2R6S7, |
| UniProt Related Accession: | Q9UBU2 |
| Molecular Weight: | 28,447 Da |
| NCBI Full Name: | Dickkopf-related protein 2 |
| NCBI Synonym Full Names: | dickkopf WNT signaling pathway inhibitor 2 |
| NCBI Official Symbol: | DKK2�� |
| NCBI Official Synonym Symbols: | DKK-2�� |
| NCBI Protein Information: | dickkopf-related protein 2 |
| UniProt Protein Name: | Dickkopf-related protein 2 |
| Protein Family: | Dickkopf-related protein |
| UniProt Gene Name: | DKK2�� |
| UniProt Entry Name: | DKK2_HUMAN |
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