Immunology Recombinant Proteins
Human Dectin/CLEC7A Recombinant Protein (RPES3272)
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- SKU:
- RPES3272
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Immunology
Description
system_update_altDatasheet
Human Dectin/CLEC7A Recombinant Protein
Dectin-1 was recently identified as the most important receptor for beta-glucan. It is a type II transmembrane protein which binds beta-1,3 and beta-1,6 glucans, and is expressed on most cells of the innate immune system and has been implicated in phagocytosis as well as killing of fungi by macrophages, neutrophils and dendritic cells. Recognition of beta-glucan by dectin-1 triggers effective immune response, including phagocytosis and proinflammatory factor production, to eliminate infecting fungi, which especially benefits immunocompromised patients against opportunistic fungal infection.
| Product Name: | Human Dectin/CLEC7A Recombinant Protein (RPES3272) |
| Product Code: | RPES3272 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | Human Cells |
| Synonyms: | Beta-glucan receptor, BGR, CD369, CLEC7A, CLECSF12, CLECSF12DC-associated C-type lectin 1,Dectin1, Dectin-1, DECTIN1CANDF4,CANDF4,DECTIN1 |
| Accession: | Q9BXN2 |
| Sequence: | Thr66-Met247 |
| Fusion tag: | N-Fc |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human Dectin-1 is produced by our Mammalian expression system and the target gene encoding Thr66-Met247 is expressed with a Fc tag at the N-terminus. |
| Purity: | > 85% as determined by reducing SDS-PAGE. |
| Mol Mass: | 46.9 kDa |
| AP Mol Mass: | 50-65 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of PBS,pH 7.4. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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