Enzymes Recombinant Proteins

Human DECR1 Recombinant Protein (RPPB1565)

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SKU:
RPPB1565
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q16698
Research Area:
Enzymes

Description

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Product Name:Human DECR1 Recombinant Protein
Product Code:RPPB1565
Size:10µg
Species:Human
Target:DECR1
Synonyms:2,4-dienoyl-CoA reductase, mitochondrial, 2,4-dienoyl-CoA reductase [NADPH], 4-enoyl-CoA reductase [NADPH], DECR1, DECR, NADPH, SDR18C1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The DECR1 solution contains 20mM Tris-HCl buffer (pH 8.0), 10% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MNTEALQSKF FSPLQKAMLP PNSFQGKVAF ITGGGTGLGK GMTTLLSSLG AQCVIASRKM DVLKATAEQI SSQTGNKVHA IQCDVRDPDM VQNTVSELIK VAGHPNIVIN NAAGNFISPT ERLSPNAWKT ITDIVLNGTA FVTLEIGKQL IKAQKGAAFL SITTIYAETG SGFVVPSASA KAGVEAMSKS LAAEWGKYGM RFNVIQPGPI KTKGAFSRLD PTGTFEKEMI GRIPCGRLGT VEELANLAAF LCSDYASWIN GAVIKFDGGE EVLISGEFND LRKVTKEQWD TIEELIRKTK GS

DECR1 is a mitochondrial protein which exists as a homotetramer and is a member of a family of short-chain dehydrogenases/reductases. DECR1 acts as an auxiliary enzyme of beta-oxidation andt partakes in the metabolism of unsaturated fatty enoyl-CoA esters. in particular, DECR1 uses NADP+ to catalyze the reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA that can subsequently be used as an intermediate in the Krebs cycle. Furthermore, DECR1 is believed to work as a tumor suppressor, possibly downregulating the expression of Neu and slowing the rate of tumorigenesis.

DECR1 Human Recombinant fused to 21 amino acid His Tag at N-terminal produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 322 amino acids (35-335 a.a.) and having a molecular mass of 34.4kDa. The DECR1 is purified by proprietary chromatographic techniques.

UniProt Protein Function:DECR1: Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3- enoyl-CoA. Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.
UniProt Protein Details:

Protein type:Oxidoreductase; EC 1.3.1.34; Mitochondrial

Chromosomal Location of Human Ortholog: 8q21.3

Cellular Component: cytoplasm; mitochondrial matrix; mitochondrion; nucleoplasm; nucleus

Molecular Function:2,4-dienoyl-CoA reductase (NADPH) activity; oxidoreductase activity, acting on NADH or NADPH

Biological Process: fatty acid beta-oxidation; protein homotetramerization

NCBI Summary:This gene encodes an accessory enzyme which participates in the beta-oxidation and metabolism of unsaturated fatty enoyl-CoA esters. [provided by RefSeq, Jul 2008]
UniProt Code:Q16698
NCBI GenInfo Identifier:3913456
NCBI Gene ID:1666
NCBI Accession:Q16698.1
UniProt Secondary Accession:Q16698,Q2M304, Q93085, B7Z6B8,
UniProt Related Accession:Q16698
Molecular Weight:
NCBI Full Name:2,4-dienoyl-CoA reductase, mitochondrial
NCBI Synonym Full Names:2,4-dienoyl-CoA reductase 1, mitochondrial
NCBI Official Symbol:DECR1��
NCBI Official Synonym Symbols:DECR; NADPH; SDR18C1��
NCBI Protein Information:2,4-dienoyl-CoA reductase, mitochondrial
UniProt Protein Name:2,4-dienoyl-CoA reductase, mitochondrial
UniProt Synonym Protein Names:2,4-dienoyl-CoA reductase [NADPH]; 4-enoyl-CoA reductase [NADPH]; Short chain dehydrogenase/reductase family 18C member 1
Protein Family:2,4-dienoyl-CoA reductase
UniProt Gene Name:DECR1��
UniProt Entry Name:DECR_HUMAN
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