Cell Biology Recombinant Proteins
Human DDR2 Kinase/CD167b Recombinant Protein (RPES2011)
- SKU:
- RPES2011
Description
Human DDR2 Kinase/CD167b Recombinant Protein
Discoidin domain receptor 2 (DDR2) or CD167b (cluster of differentiation 167b) is a kind of protein tyrosine kinases associated with cell proliferation and tumor metastasis, and collagen, identified as a ligand for DDR2, up-regulates matrix metallloproteinase 1 (MMP-1) and MMP-2 expression in cellular matrix. DDR2/CD167b was found to recognise the triple-helical region of collagen X as well as the NC1 domain. Binding to the collagenous region was dependent on the triple-helical conformation. DDR2/CD167b autophosphorylation was induced by the collagen X triple-helical region but not the NC1 domain, indicating that the triple-helical region of collagen X contains a specific DDR2 binding site that is capable of receptor activation. DDR2/CD167b is induced during stellate cell activation and implicate the phosphorylated receptor as a mediator of MMP-2 release and growth stimulation in response to type I collagen. Moreover, type I collagen-dependent upregulation of DDR2/CD167b expression establishes a positive feedback loop in activated stellate cells, leading to further proliferation and enhanced invasive activity.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
| Product Name: | Human DDR2 Kinase/CD167b Recombinant Protein (RPES2011) |
| Product Code: | RPES2011 |
| Size: | 20µg |
| Species: | Human |
| Expressed Host: | Baculovirus-Insect Cells |
| Synonyms: | CD167,MIG20a,NTRKR3,TKT,TYRO10 |
| Accession: | Q16832 |
| Sequence: | Arg422-Glu855 |
| Fusion tag: | N-His & GST |
| Activity: | The specific activity was determined to be 8 nmol/min/mg using synthetic AXLtide peptide(CKKSRGDYMTMQIG) as substrate. |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the human DDR2 (Q16832) (Arg422-Glu855) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus. |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 77.1 kDa |
| AP Mol Mass: | 77 kDa |
| Formulation: | Supplied as sterile 20mM Tris, 500mM NaCl, pH 7.4, 10% glycerol |
| Shipping: | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C. |
| Stability and Storage: | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
Additional Information
Product Type: |
Recombinant Protein |
Species: |
Human |
Research Area: |
Cell Biology |
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