Human DCUN1D2 Recombinant Protein (RPPB3341)

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RPPB3341

Description

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Product Name:Human DCUN1D2 Recombinant Protein
Product Code:RPPB3341
Size:20µg
Species:Human
Target:DCUN1D2
Synonyms:DCN1-like protein 2, DCUN1 domain-containing protein 2, Defective in cullin neddylation protein 1-like protein 2, DCUN1D2, C13orf17, DCUN1L2.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:DCUN1D2 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 30% glycerol and 0.1M NaCl.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MHKLKSSQKD KVRQFMACTQ AGERTAIYCL TQNEWRLDEA TDSFFQNPDS LHRESMRNAV DKKKLERLYG RYKDPQDENK IGVDGIQQFC DDLSLDPASI SVLVIAWKFR AATQCEFSRK EFLDGMTELG CDSMEKLKAL LPRLEQELKD TAKFKDFYQF TFTFAKNPGQ KGLDLEMAVA YWKLVLSGRF KFLDLWNTFL MEHHKRSIPR DTWNLLLDFG NMIADDMSNY DEEGAWPVLI DDFVEYARPV VTGGKRSLF

DCN1-like protein 2 (DCUN1D2) which contains one DCUN1 domain and 1 UBA-like domain, may have a role in the neddylation of cullins which regulate SCF-type ubiquitin ligase complexes. The gene encoding Dcun1D2 is located on human chromosome 13. Chromosome 13 contains major tumor suppressor genes, including BRCA2 and RB1, which are linked with breast cancer susceptibility and retinoblastoma, respectively.

DCUN1D2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 279 amino acids (1-259 a.a.) and having a molecular mass of 32.3kDa.DCUN1D2 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:DCUN1D2: May contribute to neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 13q34
UniProt Protein Details:
NCBI Summary:
UniProt Code:Q6PH85
NCBI GenInfo Identifier:62122952
NCBI Gene ID:55208
NCBI Accession:NP_001014305.1
UniProt Secondary Accession:Q6PH85,Q5JSA5, Q5JSA6, Q5JSA7, Q9NVJ1, Q9NXR6
UniProt Related Accession:Q6PH85
Molecular Weight:21,467 Da
NCBI Full Name:DCN1-like protein 2
NCBI Synonym Full Names:DCN1, defective in cullin neddylation 1, domain containing 2
NCBI Official Symbol:DCUN1D2��
NCBI Official Synonym Symbols:C13orf17��
NCBI Protein Information:DCN1-like protein 2; DCUN1 domain-containing protein 2; defective in cullin neddylation protein 1-like protein 2
UniProt Protein Name:DCN1-like protein 2
UniProt Synonym Protein Names:DCUN1 domain-containing protein 2; Defective in cullin neddylation protein 1-like protein 2
Protein Family:DCN1-like protein
UniProt Gene Name:DCUN1D2��
UniProt Entry Name:DCNL2_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q6PH85
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