Developmental Biology Recombinant Proteins
Human DCAMKL1 Recombinant Protein (RPES1198)
- SKU:
- RPES1198
Description
Human DCAMKL1 Recombinant Protein
DCAMKL1; also known as DCLK1; is a member of the protein kinase superfamily and the doublecortin family. It contains two N-terminal doublecortin domains; which bind microtubules and regulate microtubule polymerization; a C-terminal serine/threonine protein kinase domain; which shows substantial homology to Ca2+/calmodulin-dependent protein kinase; and a serine/proline-rich domain in between the doublecortin and the protein kinase domains; which mediates multiple protein-protein interactions. DCAMKL1 is involved in several different cellular processes; including neuronal migration; retrograde transport; neuronal apoptosis and neurogenesis. Its microtubule-polymerizing activity is independent of its protein kinase activity. DCAMKL1 may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. It may also participate in functions of the mature nervous system.
| Product Name: | Human DCAMKL1 Recombinant Protein (RPES1198) |
| Product Code: | RPES1198 |
| Size: | 20µg |
| Species: | Human |
| Expressed Host: | Baculovirus-Insect Cells |
| Synonyms: | CL1,CLICK1,DCAMKL1,DCDC3A,DCLK |
| Accession: | O15075-1 |
| Sequence: | Met 1-Val 705 |
| Fusion tag: | N-His & GST |
| Activity: | The specific activity was determined to be 6.1 nmol/min/mg using synthetic Autocamtide-2 peptide (KKALRRQETVDAL-amide) as substrate. |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the human DCLK1 (O15075-1) (Met 1-Val 705) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus. |
| Purity: | > 84 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 106 kDa |
| AP Mol Mass: | 105 kDa |
| Formulation: | Supplied as sterile 20mM Tris; 500mM NaCl; pH 7.4; 10% gly; 0.5mM PMSF |
| Shipping: | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt; store it immediately at<-20°C. |
| Stability and Storage: | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
Additional Information
Product Type: |
Recombinant Protein |
Species: |
Human |
Research Area: |
Developmental Biology |
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