Developmental Biology Recombinant Proteins
Human DCAMKL1 Recombinant Protein (RPES0909)
- SKU:
- RPES0909
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Developmental Biology
Description
Human DCAMKL1 Recombinant Protein
DCLK1; also known as DCAMKL1 is a member of the protein kinase superfamily and the doublecortin family. It contains two N-terminal doublecortin domains; which bind microtubules and regulate microtubule polymerization; a C-terminal serine/threonine-protein kinase domain; which shows substantial homology to Ca2+/calmodulin-dependent protein kinase; and a serine/proline-rich domain in between the doublecortin and the protein kinase domains; which mediates multiple protein-protein interactions. DCAMKL1 is linked to several cellular processes, such as neuronal migration and retrograde transport. It's also involved in neuronal apoptosis and neurogenesis. Its microtubule-polymerizing activity is independent of its protein kinase activity. DCAMKL1 may be linked to a calcium-signalling pathway that controls neuronal migration. It is part of the mature nervous system's activities. Human DCAMKL1 Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
| Product Name: | Human DCAMKL1 Recombinant Protein (RPES0909) |
| Product Code: | RPES0909 |
| Size: | 20µg |
| Species: | Human |
| Expressed Host: | Baculovirus-Insect Cells |
| Synonyms: | CL1,CLICK1,DCAMKL1,DCDC3A,DCLK |
| Accession: | O15075-1 |
| Sequence: | Met 1-Val 705 |
| Fusion tag: | |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the human DCLK1 (O15075-1) (Met 1-Val 705) was expressed and purified with two additional amino acids (Gly & Pro ) at the N-terminus. |
| Purity: | > 80 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 78.5 kDa |
| AP Mol Mass: | 64 kDa |
| Formulation: | Lyophilized from sterile 20mM Tris; 500mM NaCl; 10% glycerol; pH 7.4 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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