Developmental Biology Recombinant Proteins

Human DCAMKL1 Recombinant Protein (RPES0909)

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SKU:
RPES0909
Product Type:
Recombinant Protein
Species:
Human
Research Area:
Developmental Biology

Description

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Human DCAMKL1 Recombinant Protein

DCLK1; also known as DCAMKL1 is a member of the protein kinase superfamily and the doublecortin family. It contains two N-terminal doublecortin domains; which bind microtubules and regulate microtubule polymerization; a C-terminal serine/threonine-protein kinase domain; which shows substantial homology to Ca2+/calmodulin-dependent protein kinase; and a serine/proline-rich domain in between the doublecortin and the protein kinase domains; which mediates multiple protein-protein interactions. DCAMKL1 is linked to several cellular processes, such as neuronal migration and retrograde transport. It's also involved in neuronal apoptosis and neurogenesis. Its microtubule-polymerizing activity is independent of its protein kinase activity. DCAMKL1 may be linked to a calcium-signalling pathway that controls neuronal migration. It is part of the mature nervous system's activities. Human DCAMKL1 Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.

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