Human CYTIP Recombinant Protein (RPPB3324)

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SKU:
RPPB3324
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O60759

Description

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Product Name:Human CYTIP Recombinant Protein
Product Code:RPPB3324
Size:20µg
Species:Human
Target:CYTIP
Synonyms:Cytohesin 1 Interacting Protein, Cytohesin Binder And Regulator, PSCDBP, Pleckstrin Homology, Sec7 And Coiled-Coil Domains, Binding Protein,Pleckstrin Homology Sec7 And Coiled-Coil Domains-Binding Protein, Cytohesin-Associated Scaffolding Protein, Cytohesin Binding Protein HE, Cytohesin-Binding Protein HE, Cbp HE, CASP, CYBR, HE Pleckstrin Homology, Sec7 And Coiled/Coil Domains, Binding Protein, Cytohesin-1 Interacting Protein, Cytohesin-Interacting Protein, CYTHIP, B3-1, CYTIP.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:CYTIP protein solution (1mg/ml) containing 20mM Tris-HCl (pH 8.0) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPPGSH MGSEFMSLQR LLQHSSNGNL ADFCAGPAYS SYSTLTGSLT MDDNRRIQML ADTVATLPRG RKQLALTRSS SLSDFSWSQR KLVTVEKQDN ETFGFEIQSY RPQNQNACSS EMFTLICKIQ EDSPAHCAGL QAGDVLANIN GVSTEGFTYK QVVDLIRSSG NLLTIETLNG TMILKRTELE AKLQVLKQTL KQKWVEYRSL QLQEHRLLHG DAANCPSLEN MDLDELSLFG PLPGPGPALV DRNRLSSESS CKSWLSSMTM DSEDGYQTCV SEDSSRGAFS RQTSTDDECF IPKEGDDFLR RSSSRRNRSI SNTSSGSMSP LWEGNLSSMF GTLPRKSRKG SVRKQLLKFI PGLHRAVEEE ESRF

Cytohesin-interacting protein, also known as CYTIP contains 2 leucinezipper domains as well as a putative C-terminal nuclear targeting signal.However, CYTIP does not contain any hydrophobic regions. In addition, CYTIP isexpressed weakly in resting NK and T cells. It also modulates the activation of ARF genes byCYTH1.

CYTIP Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 384 amino acids (1-359 a.a) and having a molecular mass of 42.6kDa.CYTIP is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:PSCDBP: By its binding to cytohesin-1 (CYTH1), it modifies activation of ARFs by CYTH1 and its precise function may be to sequester CYTH1 in the cytoplasm.
UniProt Protein Details:

Protein type:Cell adhesion

Chromosomal Location of Human Ortholog: 2q11.2

Cellular Component: nucleoplasm; cytoplasm; early endosome; cell cortex

Molecular Function:protein binding

Biological Process: regulation of cell adhesion

NCBI Summary:The protein encoded by this gene contains 2 leucine zipper domains and a putative C-terminal nuclear targeting signal, but does not have any hydrophobic regions. This protein is expressed weakly in resting NK and T cells. The encoded protein modulates the activation of ARF genes by CYTH1. This protein interacts with CYTH1 and SNX27 proteins and may act to sequester CYTH1 protein in the cytoplasm.[provided by RefSeq, Aug 2008]
UniProt Code:O60759
NCBI GenInfo Identifier:47933392
NCBI Gene ID:9595
NCBI Accession:NP_004279.3
UniProt Related Accession:O60759
Molecular Weight:
NCBI Full Name:cytohesin-interacting protein
NCBI Synonym Full Names:cytohesin 1 interacting protein
NCBI Official Symbol:CYTIP��
NCBI Official Synonym Symbols:HE; B3-1; CASP; CYBR; CYTHIP; PSCDBP��
NCBI Protein Information:cytohesin-interacting protein
UniProt Protein Name:Cytohesin-interacting protein
UniProt Synonym Protein Names:Cytohesin binder and regulator; CYBR; Cytohesin-associated scaffolding protein; CASP; Cytohesin-binding protein HE; Cbp HE; Pleckstrin homology Sec7 and coiled-coil domains-binding protein
Protein Family:Cytohesin-interacting protein
UniProt Gene Name:CYTIP��
UniProt Entry Name:CYTIP_HUMAN
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