Human CYTH3 Recombinant Protein (RPPB3323)

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SKU:
RPPB3323
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O43739

Description

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Product Name:Human CYTH3 Recombinant Protein
Product Code:RPPB3323
Size:10µg
Species:Human
Target:CYTH3
Synonyms:Cytohesin 3, PSCD3, ARNO3, GRP1, PH SEC7 and Coiled-Coil Domain-Containing Protein 3 , Pleckstrin Homology Sec7 and Coiled-Coil Domains 3, General Receptor of Phosphoinositides 1 , ARF Nucleotide-Binding Site Opener 3 , Protein ARNO3 , Cytohesin-3, CYTH3.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The CYTH3 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 20% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMDEDGGG EGGGVPEDLS LEEREELLDI RRRKKELIDD IERLKYEIAE VMTEIDNLTS VEESKTTQRN KQIAMGRKKF NMDPKKGIQF LIENDLLQSS PEDVAQFLYK GEGLNKTVIG DYLGERDEFN IKVLQAFVEL HEFADLNLVQ ALRQFLWSFR LPGEAQKIDR MMEAFASRYC LCNPGVFQST DTCYVLSFAI IMLNTSLHNH NVRDKPTAER FIAMNRGINE GGDLPEELLR NLYESIKNEP FKIPEDDGND LTHTFFNPDR EGWLLKLGGR VKTWKRRWFI LTDNCLYYFE YTTDKEPRGI IPLENLSIRE VEDPRKPNCF ELYNPSHKGQ VIKACKTEAD GRVVEGNHVV YRISAPSPEE KEEWMKSIKA SISRDPFYDM LATRKRRIAN KK

Cytohesin 3 (CYTH3) belongs to the PSCD family, whose members have identical structural organization which consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain, and seem to mediate the regulation of protein sorting and membrane trafficking. CYTH3 is involved in the regulation of Golgi structure and function, and it might have a physiological role in regulating ADP-ribosylation factor protein 6 (ARF) functions, in addition to acting on ARF1.

CYTH3 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 422 amino acids (1-399) and having a molecular mass of 48.7 kDa.CYTH3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:cytohesin 3: Promotes guanine-nucleotide exchange on ARF1. Promotes the activation of ARF through replacement of GDP with GTP. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Receptor, misc.; GEFs; GEFs, ARF; Lipid-binding; Nuclear receptor co-regulatorChromosomal Location of Human Ortholog: 7p22.1Cellular Component: ruffle; extrinsic to internal side of plasma membrane; plasma membrane; trans-Golgi network; cytosolMolecular Function: phosphatidylinositol-3,4,5-triphosphate binding; ARF guanyl-nucleotide exchange factor activityBiological Process: regulation of cell adhesion; vesicle-mediated transport; positive regulation of cell adhesion; regulation of ARF protein signal transduction; positive regulation of GTPase activity; Golgi vesicle transport
UniProt Protein Details:
NCBI Summary:This gene encodes a member of the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. PSCD family members have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This encoded protein is involved in the control of Golgi structure and function, and it may have a physiological role in regulating ADP-ribosylation factor protein 6 (ARF) functions, in addition to acting on ARF1. [provided by RefSeq, Jul 2008]
UniProt Code:O43739
NCBI GenInfo Identifier:13124042
NCBI Gene ID:9265
NCBI Accession:O43739.2
UniProt Secondary Accession:O43739
UniProt Related Accession:O43739
Molecular Weight:
NCBI Full Name:Cytohesin-3
NCBI Synonym Full Names:cytohesin 3
NCBI Official Symbol:CYTH3��
NCBI Official Synonym Symbols:GRP1; ARNO3; PSCD3; cytohesin-3��
NCBI Protein Information:cytohesin-3
UniProt Protein Name:Cytohesin-3
UniProt Synonym Protein Names:ARF nucleotide-binding site opener 3; Protein ARNO3; General receptor of phosphoinositides 1; Grp1; PH, SEC7 and coiled-coil domain-containing protein 3
Protein Family:
UniProt Gene Name:CYTH3��
UniProt Entry Name:CYH3_HUMAN
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