Enzymes Recombinant Proteins

Human Cyclophilin C Recombinant Protein (RPPB1538)

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SKU:
RPPB1538
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P45877
Research Area:
Enzymes

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Human Cyclophilin C Recombinant Protein
Product Code:RPPB1538
Size:10µg
Species:Human
Target:Cyclophilin C
Synonyms:Peptidylprolyl Isomerase C (Cyclophilin C), Cyclophilin C, Rotamase C, EC 5.2.1.8, PPIase C, CYPC, Peptidyl-Prolyl Cis-Trans Isomerase C, Parvulin, PPIC.
Source:Escherichia Coli
Physical Appearance:Filtered White lyophilized (freeze-dried) powder.
Formulation:Cyclophilin-C was filtered (0.4 �m) and lyophilized in 20mM Tris buffer and 50mM NaCl, pH 7.5.
Solubility:It is recommended to add 200�l of deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. Cyclophilin-C is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
Stability:Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MKHHHHHHASFRKRGPSVTA KVFFDVRIGD KDVGRIVIGL FGKVVPKTVE NFVALATGEK GYGYKGSKFH RVIKDFMIQG GDITTGDGTG GVSIYGETFP DENFKLKHYG IGWVSMANAG PDTNGSQFFI TLTKPTWLDG KHVVFGKVID GMTVVHSIEL QATDGHDRPL TNCSIINSGK IDVKTPFVVE IADW

Cyclophilin-C belongs to the peptidyl-prolyl cis-trans isomerase (PPIase)) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. Like other PPIases, the Cyclophilin-C protein can bind immunosuppressant cyclosporin A.

Cyclophilin-C Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain (Phe29-Trp212) containing 194 amino acids including a 10 aa His tag at N-terminus. The total calculated molecular mass is 21.3kDa.

UniProt Protein Function:PPIC: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Belongs to the cyclophilin-type PPIase family.
UniProt Protein Details:

Protein type:EC 5.2.1.8; Isomerase; Cyclophilin

Chromosomal Location of Human Ortholog: 5q23.2

Molecular Function:cyclosporin A binding; peptidyl-prolyl cis-trans isomerase activity; protein binding

NCBI Summary:The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase)) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. Similar to other PPIases, this protein can bind immunosuppressant cyclosporin A. [provided by RefSeq, Jul 2008]
UniProt Code:P45877
NCBI GenInfo Identifier:1169178
NCBI Gene ID:5480
NCBI Accession:P45877.1
UniProt Secondary Accession:P45877,A4LBB5,
UniProt Related Accession:P45877
Molecular Weight:22,763 Da
NCBI Full Name:Peptidyl-prolyl cis-trans isomerase C
NCBI Synonym Full Names:peptidylprolyl isomerase C
NCBI Official Symbol:PPIC��
NCBI Official Synonym Symbols:CYPC��
NCBI Protein Information:peptidyl-prolyl cis-trans isomerase C
UniProt Protein Name:Peptidyl-prolyl cis-trans isomerase C
UniProt Synonym Protein Names:Cyclophilin C; Rotamase C
Protein Family:Peptidyl-prolyl cis-trans isomerase
UniProt Gene Name:PPIC��
UniProt Entry Name:PPIC_HUMAN
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