Human CXCR4 (C28A) Recombinant Protein (His Tag) (RPES6530)

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SKU:
RPES6530
Product Type:
Recombinant Protein
Species:
Human

Description

Product Name:Human CXCR4 (C28A) Recombinant Protein (His Tag)
Product Code:RPES6530
Size:20µg
Species:Human
Expression Host:E.coli
Synonyms:C-X-C chemokine receptor type 4, CD184, FB22, Fusin, HM89, HSY3RR, LAP3, LCR1, NPYR, SDF 1 receptor, WHIM
Application:ELISA, Western blot
Mol Mass:31.2 kDa
AP Mol Mass:32-35 kDa
Tag:N-GST
Purity:> 95 % as determined by reducing SDS-PAGE.
Endotoxin Level:Please contact us for more information.
Bio Activity:Testing in progress
Sequence:Met1-Lys38
Accession:P61073
Storage:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Formulation:Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
Reconstitution:Please refer to the printed manual for detailed information.
Background:Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ions levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhance intracellular calcium ions and reduce cellular cAMP levels. Involved in haematopoiesis and in cardiac ventricular septum formation. Plays also an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Could be involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus.
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