Immune Checkpoint Recombinant Proteins

Human CXCR2 Recombinant Protein (hFc Tag) (HDPT0333)

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SKU:
HDPT0333
Product Type:
Recombinant Protein
Species:
Human
Research Area:
Immune Checkpoint

Description

Human CXCR2 Recombinant Protein (hFc Tag)

Description:The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]
Product name:Human CXCR2 Recombinant Protein (hFc Tag)
Synonyms:CD182, CDw128b, CMKAR2, IL8R2, IL8RA, IL8RB
Type:protein
Size:50 µg
Name:CXCR2
Origin:Human
Source:HEK293
Protein Type:Recombinant
Application:Contact Technical Support
Purity:Contact Technical Support
Purification:affinity purification
Format:Lyophilized
Conjugate:C-Human Fc
Storage:Store at -80°C for 12 months (Avoid repeated freezing and thawing)
Usage:Research use only
Buffer:Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
Reconstitution:Reconstitute with deionized water
Sequence:CXCR2(Met1-Lys48)+hFc(Glu99-Ala330)
Gene ID:
Uniprot:P25025
Molecular Weight:40.81 kDa
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