Human CXADR Recombinant Protein (RPPB3316)
- SKU:
- RPPB3316
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P78310
Description
| Product Name: | Human CXADR Recombinant Protein |
| Product Code: | RPPB3316 |
| Size: | 20µg |
| Species: | Human |
| Target: | CXADR |
| Synonyms: | Coxsackie Virus And Adenovirus Receptor, CAR, 46 KD Coxsackievirus And Adenovirus Receptor (CAR) Protein 11, Coxsackievirus B-Adenovirus Receptor, HCVADR, CVB3-Binding Protein, CAR4/6, HCAR. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The CXADR solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 1mM DTT and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSLSITTPE EMIEKAKGET AYLPCKFTLS PEDQGPLDIE WLISPADNQK VDQVIILYSG DKIYDDYYPD LKGRVHFTSN DLKSGDASIN VTNLQLSDIG TYQCKVKKAP GVANKKIHLV VLVKPSGARC YVDGSEEIGS DFKIKCEPKE GSLPLQYEWQ KLSDSQKMPT SWLAEMTSSV ISVKNASSEY SGTYSCTVRN RVGSDQCLLR LNVVPPSNKA G |
CXADR is a component of the epithelial apical junction complex which operates as an homophilic cell adhesion molecule and is crucial for tight junction integrity. CXADR also takes part in transepithelial relocation of leukocytes through adhesive interactions with AMICA1/JAML a transmembrane protein of the plasma membrane of leukocytes. A number of transcript variants encoding different isoforms were identified for this gene. Pseudogenes of this gene were located on chromosomes 15, 18, and 21.
CXADR Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 241 amino acids (20-237) and having a molecular mass of 26.0kDa.CXADR is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CXADR: a component of the epithelial apical junction complex that is essential for the tight junction integrity. Proposed to function as a homophilic cell adhesion molecule. Recruits MPDZ to intercellular contact sites. Probably involved in transepithelial migration of polymorphonuclear leukocytes (PMN) through adhesive interactions with AMICA1 located in the plasma membrane of PMN. |
| UniProt Protein Details: | Protein type:Cell adhesion; Receptor, misc.; Membrane protein, integral Chromosomal Location of Human Ortholog: 21q21.1 Cellular Component: extracellular space; neuron projection; tight junction; protein complex; basolateral plasma membrane; apicolateral plasma membrane; integral to plasma membrane; extracellular region; acrosome; intercellular junction; lipid raft; nucleoplasm; growth cone; adherens junction; plasma membrane; cell junction; neuromuscular junction; filopodium Molecular Function:viral receptor activity; integrin binding; identical protein binding; protein binding; beta-catenin binding; cell adhesion molecule binding; PDZ domain binding; receptor binding Biological Process: intercellular junction assembly and maintenance; mitochondrion organization and biogenesis; neutrophil chemotaxis; entry of virus into host cell; regulation of immune response; heart development; gamma-delta T cell activation; heterophilic cell adhesion; cardiac muscle fiber development; actin cytoskeleton reorganization; homotypic cell-cell adhesion; germ cell migration; blood coagulation; defense response to virus; leukocyte migration |
| NCBI Summary: | The protein encoded by this gene is a type I membrane receptor for group B coxsackieviruses and subgroup C adenoviruses. Several transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene are found on chromosomes 15, 18, and 21. [provided by RefSeq, May 2011] |
| UniProt Code: | P78310 |
| NCBI GenInfo Identifier: | 6685351 |
| NCBI Gene ID: | 1525 |
| NCBI Accession: | P78310.1 |
| UniProt Secondary Accession: | P78310,O00694, Q8WWT6, Q8WWT7, Q8WWT8, Q9UKV4, B2R8V8 B7WPI3, D3YHP0, |
| UniProt Related Accession: | P78310 |
| Molecular Weight: | 35,570 Da |
| NCBI Full Name: | Coxsackievirus and adenovirus receptor |
| NCBI Synonym Full Names: | coxsackie virus and adenovirus receptor |
| NCBI Official Symbol: | CXADR�� |
| NCBI Official Synonym Symbols: | CAR; HCAR; CAR4/6�� |
| NCBI Protein Information: | coxsackievirus and adenovirus receptor; 46 kD coxsackievirus and adenovirus receptor (CAR) protein; CVB3-binding protein; HCVADR; coxsackievirus B-adenovirus receptor |
| UniProt Protein Name: | Coxsackievirus and adenovirus receptor |
| UniProt Synonym Protein Names: | CVB3-binding protein; Coxsackievirus B-adenovirus receptor; HCVADR |
| Protein Family: | CXADR-like membrane protein |
| UniProt Gene Name: | CXADR�� |
| UniProt Entry Name: | CXAR_HUMAN |
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