Enzymes Recombinant Proteins

Human CTSZ Recombinant Protein (RPPB5807)

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SKU:
RPPB5807
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9UBR2
Research Area:
Enzymes

Description

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Product Name:Human CTSZ Recombinant Protein
Product Code:RPPB5807
Size:5µg
Species:Human
Target:CTSZ
Synonyms:Cathepsin Z, Cathepsin X, Cysteine-Type Carboxypeptidase, Lysosomal Carboxypeptidase B, Carboxypeptidase LB, Cathepsin B2, Cathepsin IV, Cathepsin Z1, Cathepsin P, Cathepsin Y, EC 3.4.18.1, Preprocathepsin P, CTSX.
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered clear solution.
Formulation:CTSZ protein solution (0.5mg/ml) contains 10% glycerol & Phosphate Buffered Saline (pH 7.4).
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:GLYFRRGQTC YRPLRGDGLA PLGRSTYPRP HEYLSPADLP KSWDWRNVDG VNYASITRNQHIPQYCGSCW AHASTSAMAD RINIKRKGAW PSTLLSVQNV IDCGNAGSCE GGNDLSVWDYAHQHGIPDET CNNYQAKDQE CDKFNQCGTC NEFKECHAIR NYTLWRVGDY GSLSGREKMMAEIYANGPIS CGIMATERLA NYTGGIYAEY QDTTYINHVV SVAGWGISDG TEYWIVRNSWGEPWGERGWL RIVTSTYKDG KGARYNLAIE EHCTFGDPIV LEHHHHHH
Biological Activity:The specific activity is determent as the ability of 1 unit to convert 1.0 pmole of Mca-PLGL-Dpa-AR-NH2 to MCA- Pro-Leu-OH per minute at pH 3.5 at 25C and is > 1,400 pmol/min/ug.

Cathepsin-Z (CTSZ) is a lysosomal cysteine proteinase and a member of the peptidase C1 family. CTSZ, which is known also as cathepsin X and cathepsin P, exhibits carboxy-monopeptidase and carboxy-dipeptidase activities. CTSZ is expressed ubiquitously in cancer cell lines and primary tumors and as other members of this family, takes part in tumorigenesis.

CTSZ produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 288 amino acids (24-303.a.) and having a molecular mass of 32.5kDa. (Molecular size on SDS-PAGE will appear at approximately 28-40kDa).CTSZ is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.�

UniProt Protein Function:CTSZ: Exhibits carboxy-monopeptidase as well as carboxy- dipeptidase activity. Belongs to the peptidase C1 family.
UniProt Protein Details:

Protein type:EC 3.4.18.1; Protease

Chromosomal Location of Human Ortholog: 20q13.32

Cellular Component: extracellular space; intracellular membrane-bound organelle; lysosome; endoplasmic reticulum; plasma membrane

Molecular Function:cysteine-type peptidase activity

Biological Process: cellular protein metabolic process; angiotensin maturation; proteolysis

Disease: Mycobacterium Tuberculosis, Susceptibility To

NCBI Summary:The protein encoded by this gene is a lysosomal cysteine proteinase and member of the peptidase C1 family. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. The encoded protein has also been known as cathepsin X and cathepsin P. This gene is expressed ubiquitously in cancer cell lines and primary tumors and, like other members of this family, may be involved in tumorigenesis. [provided by RefSeq, Oct 2008]
UniProt Code:Q9UBR2
NCBI GenInfo Identifier:12643324
NCBI Gene ID:1522
NCBI Accession:Q9UBR2.1
UniProt Secondary Accession:Q9UBR2,O75331, Q9UQV5, Q9UQV6, B2RC40,
UniProt Related Accession:Q9UBR2
Molecular Weight:303
NCBI Full Name:Cathepsin Z
NCBI Synonym Full Names:cathepsin Z
NCBI Official Symbol:CTSZ��
NCBI Official Synonym Symbols:CTSX��
NCBI Protein Information:cathepsin Z; cathepsin P; cathepsin X; cathepsin Y; cathepsin B2; cathepsin IV; cathepsin Z1; preprocathepsin P; carboxypeptidase LB; lysosomal carboxypeptidase B; cysteine-type carboxypeptidase
UniProt Protein Name:Cathepsin Z
UniProt Synonym Protein Names:Cathepsin P; Cathepsin X
Protein Family:Cathepsin
UniProt Gene Name:CTSZ��
UniProt Entry Name:CATZ_HUMAN
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