Enzymes Recombinant Proteins

Human CTSZ Recombinant Protein (RPPB1525)

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SKU:
RPPB1525
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9UBR2
Research Area:
Enzymes

Description

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Product Name:Human CTSZ Recombinant Protein
Product Code:RPPB1525
Size:20µg
Species:Human
Target:CTSZ
Synonyms:Cathepsin Z preproprotein, Cathepsin Z, CTSX, Cathepsin P, Cathepsin X, CTSZ, Cathepsin-Z.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The CTSZ solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSLPKSWDW RNVDGVNYAS ITRNQHIPQY CGSCWAHAST SAMADRINIK RKGAWPSTLL SVQNVIDCGN AGSCEGGNDL SVWDYAHQHG IPDETCNNYQ AKDQECDKFN QCGTCNEFKE CHAIRNYTLW RVGDYGSLSG REKMMAEIYA NGPISCGIMA TERLANYTGG IYAEYQDTTY INHVVSVAGW GISDGTEYWI VRNSWGEPWG ERGWLRIVTS TYKDGKGARY NLAIEEHCTF GDPIV

Cathepsin-Z (CTSZ) is a lysosomal cysteine proteinase and member of the peptidase C1 family. CTSZ, which has been also known as cathepsin X and cathepsin P, exhibits carboxy-monopeptidase and carboxy-dipeptidase activities. CTSZ is expressed ubiquitously in cancer cell lines and primary tumors and, similar to other members of this family, takes part in tumorigenesis.

CTSZ Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 265 amino acids (62-303) and having a molecular mass of 29.5kDa.CTSZ is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:CTSZ: Exhibits carboxy-monopeptidase as well as carboxy- dipeptidase activity. Belongs to the peptidase C1 family.
UniProt Protein Details:

Protein type:EC 3.4.18.1; Protease

Chromosomal Location of Human Ortholog: 20q13.32

Cellular Component: extracellular space; intracellular membrane-bound organelle; lysosome; endoplasmic reticulum; plasma membrane

Molecular Function:cysteine-type peptidase activity

Biological Process: cellular protein metabolic process; angiotensin maturation; proteolysis

Disease: Mycobacterium Tuberculosis, Susceptibility To

NCBI Summary:The protein encoded by this gene is a lysosomal cysteine proteinase and member of the peptidase C1 family. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. The encoded protein has also been known as cathepsin X and cathepsin P. This gene is expressed ubiquitously in cancer cell lines and primary tumors and, like other members of this family, may be involved in tumorigenesis. [provided by RefSeq, Oct 2008]
UniProt Code:Q9UBR2
NCBI GenInfo Identifier:12643324
NCBI Gene ID:1522
NCBI Accession:Q9UBR2.1
UniProt Secondary Accession:Q9UBR2,O75331, Q9UQV5, Q9UQV6, B2RC40,
UniProt Related Accession:Q9UBR2
Molecular Weight:303
NCBI Full Name:Cathepsin Z
NCBI Synonym Full Names:cathepsin Z
NCBI Official Symbol:CTSZ��
NCBI Official Synonym Symbols:CTSX��
NCBI Protein Information:cathepsin Z; cathepsin P; cathepsin X; cathepsin Y; cathepsin B2; cathepsin IV; cathepsin Z1; preprocathepsin P; carboxypeptidase LB; lysosomal carboxypeptidase B; cysteine-type carboxypeptidase
UniProt Protein Name:Cathepsin Z
UniProt Synonym Protein Names:Cathepsin P; Cathepsin X
Protein Family:Cathepsin
UniProt Gene Name:CTSZ��
UniProt Entry Name:CATZ_HUMAN
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